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Series GSE56814 Query DataSets for GSE56814
Status Public on Jun 01, 2016
Title Gene expression study of blood monocytes in pre- and postmenopausal females with low or high bone mineral density (HuEx-1_0-st-v2)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Comparison of circulating monocytes from pre- and postmenopausal females with low or high bone mineral density (BMD). Circulating monocytes are progenitors of osteoclasts, and produce factors important to bone metabolism. Results provide insight into the role of monocytes in osteoporosis.
We identify osteoporosis genes by microarray analyses of monocytes in high vs. low hip BMD (bone mineral density) subjects.
 
Overall design Microarray analyses of monocytes were performed using Affymetrix 1.0 ST arrays in 73 Caucasian females (age: 47-56) with extremely high (mean ZBMD =1.38, n=42, 16 pre- and 26 postmenopausal subjects) or low hip BMD (mean ZBMD=-1.05, n=31, 15 pre- and 16 postmenopausal subjects). Differential gene expression analysis in high vs. low BMD subjects was conducted in the total cohort as well as pre- and post-menopausal subjects.
 
Contributor(s) Liu Y, Zhou Y, Liu Y, Zhang L, Li J, Tian Q, Zhang J, Deng H
Citation(s) 30056508, 31073748, 29330445
Submission date Apr 15, 2014
Last update date Sep 19, 2019
Contact name Yao-Zhong Liu
Organization name Tulane University School of Public Health
Department Dept. of Biostatistics and Bioinformatics
Lab Center for Bioinformatics and Genomics
Street address 1440 Canal Street, Suite 2001
City New Orleans
State/province LA
ZIP/Postal code 70112
Country USA
 
Platforms (1)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (73)
GSM1369683 Monocytes from a postmenopausal high BMD woman (DS09 PostH.CEL)
GSM1369684 Monocytes from a postmenopausal high BMD woman (DS117 PostH.CEL)
GSM1369685 Monocytes from a postmenopausal high BMD woman (DS13 PostH.CEL)
This SubSeries is part of SuperSeries:
GSE56816 Gene expression study of blood monocytes in pre- and postmenopausal females with low or high bone mineral density
Relations
BioProject PRJNA244673

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE56814_RAW.tar 1.7 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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