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| Status |
Public on Dec 24, 2013 |
| Title |
Gene expression signatures in the skin of focal palmoplantar keratoderma (FPPK) patients |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We identified a number of affected pathways through transcriptome analysis on the skin biopsy samples of the FPPK patients. Our findings suggest that TRPV3 dysfunction may increase apoptotic activity, inhibit keratinocyte differentiation and disturb the intricate balance between proliferation and differentiation state of keratinocytes in the skin.
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| Overall design |
From a 37-year-old Chinese male (II-7) and his 12-year-old son (III-7), biopsies from unaffected and affected skin tissues were obtained and their transcriptome profiles were analyzed in order to identify molecular changes related with the pathology of FPPK.
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| Contributor(s) |
He Y, Wang K |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 23, 2013 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Ji-Hoon Cho |
| E-mail(s) |
[email protected]
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| Organization name |
Institute for Systems Biology
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| Street address |
401 Terry Avenue North
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| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98109 |
| Country |
USA |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE53616 |
Gene expression signatures in the skin of focal palmoplantar keratoderma (FPPK) patients, and cell lines transfected with mutant TRPV3 |
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| Relations |
| BioProject |
PRJNA232488 |
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