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| Status |
Public on Feb 20, 2014 |
| Title |
Genome-wide espression kinetics of children progressing to clinical Type 1 diabetes (T1D). |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To unravel genes and molecular pathways involved in the pathogenesis of type 1 diabetes (T1D), we performed genome-wide gene expression profiling of prospective venous blood samples from children developing T1D-associated autoantibodies or progressing towards clinical diagnosis.
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| Overall design |
247 peripheral blood RNA samples from 18 prediabetic children and their matched controls were analyzed with Illumina Human HT-12 Expression BeadChips version 3 arrays, in order to study the gene expression changes occuring during the pathogenesis of Type 1 diabetes (T1D). Each case child (with T1D-specific autoantibodies) was matched with a persistently autoantibody-negative control child, with the same HLA-DQB1 risk category, gender, and place and date of birth. Two control children were selected for T1D cases 3, 5, 13 and 17. Seroconversion is determined as the first detection of T1D-specific autoantibody/autoantibodies (ICA titre >4 JDFU, IAA >3.47 RU, GADA >5.4 RU, IA-2A >0.43 RU, ZnT8A >0.61 RU).
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| Contributor(s) |
Kallionpää H, Elo LL, Mykkänen J, Laajala E, Vaarma M, Laajala TD, Hyöty H, Ilonen J, Veijola R, Simell T, Knip M, Lähdesmäki H, Simell O, Lahesmaa R, Ricaño-Ponce I, Wijmenga C |
| Citation(s) |
24550192, 29119244 |
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| Submission date |
Jun 24, 2011 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Henna Kallionpää |
| E-mail(s) |
[email protected]
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| Phone |
+358-2-333-8001
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| Organization name |
University of Turku
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| Department |
Turku Centre for Biotechnology
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| Lab |
Riitta Lahesmaa
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| Street address |
P.O. Box 123
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| City |
Turku |
| ZIP/Postal code |
FIN-20521 |
| Country |
Finland |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (247)
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| This SubSeries is part of SuperSeries: |
| GSE30211 |
Gene expression changes during Type 1 diabetes pathogenesis |
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| Relations |
| BioProject |
PRJNA155103 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30210_RAW.tar |
6.2 Mb |
(http)(custom) |
TAR |
| GSE30210_non_normalized.txt.gz |
76.6 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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