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| Status |
Public on Oct 21, 2024 |
| Title |
Expression data from glioblastoma derived xenograft and original glioblastoma tumors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Amplification of the epidermal growth factor receptor (EGFR, A0 for non-amplified and A1 for amplified) gene is one of the most common oncogenic alterations in glioblastoma (45%) making it a prime target for therapy. However, small molecule inhibitors of the EGFR tyrosine kinase showed disappointing efficacy in clinical trials for glioblastoma. Here we report expression data for 33 samples including 6 GBM derived xenografts (3 controls and 3 treated by tyrosine kinase inhibitor gefitinib) and 27 glioblastoma tumors (11 controls and 16 treated by tyrosine kinase inhibitor gefitinib). Note that T0, T1 and T2 treatment types mean that control, Gefitinib treatment and Gefitinib treatment (but not according to protocol schedule), respectively.
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| Overall design |
33 samples including 6 (3 controls and 3 treated by gefitinib) GBM derived xenografts and 27 (11 controls and 16 treated by gefitinib) glioblastoma tumors
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| Contributor(s) |
Bady P, Hegi ME |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 14, 2024 |
| Last update date |
Oct 22, 2024 |
| Contact name |
Pierre Bady |
| E-mail(s) |
[email protected]
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| Phone |
0041 21 692 40 95
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| Organization name |
CHUV / BCF / SIB
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| Department |
Swiss Institute of Bioinformatics
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| Lab |
Bioinformatics Core Facility
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| Street address |
Quartier UNIL-Sorge
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| City |
Lausanne |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (33)
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| GSM8569833 |
human GBM ZH-01, 2482 |
| GSM8569834 |
human GBM ZH-04, 2484 |
| GSM8569835 |
human GBM ZH-05, 2485 |
| GSM8569836 |
human GBM ZH-06, 2486 |
| GSM8569837 |
human GBM ZH-07, 2487 |
| GSM8569838 |
human GBM ZH-08, 2488 |
| GSM8569839 |
human GBM ZH-09, 2489 |
| GSM8569840 |
human GBM ZH-11, 2490 |
| GSM8569841 |
human GBM ZH-12, 2491 |
| GSM8569842 |
human GBM ZH-13, 2492 |
| GSM8569843 |
human GBM ZH-14, 2493 |
| GSM8569844 |
human GBM ZH-17, 2496 |
| GSM8569845 |
human GBM 2497, 2497 |
| GSM8569846 |
human GBM 2499, 2499 |
| GSM8569847 |
human GBM 2500, 2500 |
| GSM8569848 |
human GBM 2501, 2501 |
| GSM8569849 |
human GBM 2502, 2502 |
| GSM8569850 |
human GBM 2504, 2504 |
| GSM8569851 |
human GBM 2506, 2506 |
| GSM8569852 |
human GBM 2507, 2507 |
| GSM8569853 |
human GBM 2508, 2508 |
| GSM8569854 |
human GBM 2509, 2509 |
| GSM8569855 |
human GBM ZH-18, 2511 |
| GSM8569856 |
human GBM 2513, 2513 |
| GSM8569857 |
human GBM NCH1152, 1152 |
| GSM8569858 |
human GBM NCH1154, 1154 |
| GSM8569859 |
human GBM NCH1155, 1155 |
| GSM8569860 |
human GBM NCH1157, 1157 |
| GSM8569861 |
human GBM NCH1159, 1159 |
| GSM8569862 |
human GBM NCH1161, 1161 |
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| Relations |
| BioProject |
PRJNA1172693 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE279426_RAW.tar |
153.2 Mb |
(http)(custom) |
TAR (of CEL) |
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