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Series GSE272804 Query DataSets for GSE272804
Status Public on Jul 31, 2024
Title Bombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BIP
Organism Bombyx mori
Experiment type Expression profiling by high throughput sequencing
Summary Ubiquitin-fold modifier 1 (UFM1) is attached to protein substrates through the sequential activity of an E1 (UBA5)-E2 (UBC1)-E3 (UBL1) cascade. UFBP1 is a conserved UFL1-interacting protein in mammals. However, there is no study on UFBP1 in silkworm yet. In this study, we identified a UFBP1 ortholog in B. mori genome. Spatio-Temporal expression profiles showed that BmUFBP1 expression was highly in midgut, fatbody, and at the moth stage. BmUFBP1 knockdown inhibited ER-stress induced ER chaperone expression and BmNPV proliferation, while BmUFBP1 overexpression increased BmNPV proliferation. Furthermore, RNA sequencing and experimental verification identified the HSP70 family member BmBIP as the BmUFBP1 downstream target in regulating BmNPV proliferation. Overall, these results suggest that BmUFBP1 facilitates BmNPV proliferation via ATF6-BIP signaling.
 
Overall design siNC siUFBP1
 
Contributor(s) Meng H
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jul 22, 2024
Last update date Jul 31, 2024
Contact name Meng hao nan
E-mail(s) [email protected]
Phone 18112808186
Organization name An hui Agricultural
Department College of life
Lab PI
Street address An hui Agricultural
City hefei
State/province An hui
ZIP/Postal code 230036
Country China
 
Platforms (1)
GPL34106 DNBSEQ-T7 (Bombyx mori)
Samples (6)
GSM8412817 siNC-1
GSM8412818 siNC-2
GSM8412819 siNC-3
Relations
BioProject PRJNA1138767

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Supplementary file Size Download File type/resource
GSE272804_ref_trans_full_table.xls.gz 2.1 Mb (ftp)(http) XLS
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Raw data are available in SRA

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