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Series GSE269071 Query DataSets for GSE269071
Status Public on Sep 26, 2024
Title Inhibition of CDK8/CDK19 with the small molecule inhibitor SEL120-34A in prostate cancer cell lines (3’ tag DGE)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The Mediator complex is a multi-subunit protein that modulates gene expression on a genome-wide scale. MED12 and cyclin-dependent kinase 8 (CDK8) or its paralog CDK19 are components of its kinase module that regulate the proliferation of prostate cancer cells. In this study, we investigated how MED12 and CDK8/19 influence cancer-driven processes in prostate cancer cell lines, focusing on AR activity and enzalutamide resistance.
 
Overall design To investigate if CDK8/CDK19 inhibition has similar effects as downregulation of MED12 in enzalutamide sensitive and resistant prostate cancer cells, we treated the cells with SEL120-34A and analyzed the response using high-throughput 3’ tag differential gene expression analysis.
 
Contributor(s) Andofi C, Handle F, Culig Z
Citation(s) 39253786
Submission date Jun 04, 2024
Last update date Sep 26, 2024
Contact name Florian Handle
E-mail(s) [email protected]
Organization name Medical University of Innsbruck
Department Institute of Pathology, Neuropathology and Molecular Pathology
Street address Müllerstrasse 44
City Innsbruck
ZIP/Postal code 6020
Country Austria
 
Platforms (1)
GPL34284 Illumina NovaSeq X Plus (Homo sapiens)
Samples (14)
GSM8305850 LNCaP, DMSO, rep1
GSM8305851 LNCaP, DMSO, rep2
GSM8305852 LNCaP, DMSO, rep3
Relations
BioProject PRJNA1120051

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE269071_count_file.txt.gz 802.9 Kb (ftp)(http) TXT
GSE269071_log2CPM_expression.txt.gz 610.3 Kb (ftp)(http) TXT
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