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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 15, 2023 |
| Title |
Identify the key signaling pathway involved in the Tet2 deficiency-induced clonal hematopoiesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the signaling pathway required for the Tet2 mutant associated clonal hematopoiesis, we identified the activated signaling pathway in Tet2-deficient hematopoietic stem/progenitor cells compared to WT cells and using transgentic mouse model to validate our findings. In short, the cGAS-STING pathway is activated in Tet2-deficient HSPCs and promotes the development of CH associated with Tet2 deficiency.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for WT and Tet2-deficient hematopoietic stem/progenitor cells
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| Contributor(s) |
Xie J, Shi Y |
| Citation(s) |
37816954 |
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| Submission date |
May 12, 2023 |
| Last update date |
Dec 14, 2023 |
| Contact name |
Shaoqin Rong |
| E-mail(s) |
[email protected]
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| Organization name |
Fudan University
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| Street address |
138 Yi Xue Yuan Road
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| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (55)
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| GSM7329732 |
GMP, WT2 |
| GSM7329733 |
MEP, WT2 |
| GSM7329734 |
CLP, WT2 |
| GSM7329735 |
LT-HSC, WT3 |
| GSM7329736 |
ST-HSC, WT3 |
| GSM7329737 |
CMP, WT3 |
| GSM7329738 |
GMP, WT3 |
| GSM7329739 |
MEP, WT3 |
| GSM7329740 |
CLP, WT3 |
| GSM7329741 |
CMP, WT4 |
| GSM7329742 |
GMP, WT4 |
| GSM7329743 |
MEP, WT4 |
| GSM7329744 |
CLP, WT4 |
| GSM7329745 |
LT-HSC, WT5 |
| GSM7329746 |
ST-HSC, WT5 |
| GSM7329747 |
CMP, WT5 |
| GSM7329748 |
GMP, WT5 |
| GSM7329749 |
MEP, WT5 |
| GSM7329750 |
CLP, WT5 |
| GSM7329751 |
LT-HSC, KO2 |
| GSM7329752 |
ST-HSC, KO2 |
| GSM7329753 |
CMP, KO2 |
| GSM7329754 |
GMP, KO2 |
| GSM7329755 |
MEP, KO2 |
| GSM7329756 |
CLP, KO2 |
| GSM7329757 |
LT-HSC, KO3 |
| GSM7329758 |
ST-HSC, KO3 |
| GSM7329759 |
CMP, KO3 |
| GSM7329760 |
GMP, KO3 |
| GSM7329761 |
MEP, KO3 |
| GSM7329762 |
CLP, KO3 |
| GSM7329763 |
LT-HSC, KO4 |
| GSM7329764 |
ST-HSC, KO4 |
| GSM7329765 |
CMP, KO4 |
| GSM7329766 |
GMP, KO4 |
| GSM7329767 |
MEP, KO4 |
| GSM7329768 |
CLP, KO4 |
| GSM7329769 |
LT-HSC, KO5 |
| GSM7329770 |
ST-HSC, KO5 |
| GSM7329771 |
CMP, KO5 |
| GSM7329772 |
GMP, KO5 |
| GSM7329773 |
MEP, KO5 |
| GSM7329774 |
CLP, KO5 |
| GSM7329775 |
LT-HSC, DKO-1 |
| GSM7329776 |
LT-HSC, DKO-2 |
| GSM7329777 |
LT-HSC, DKO-3 |
| GSM7329778 |
LT-HSC, StingKO-1 |
| GSM7329779 |
LT-HSC, StingKO-2 |
| GSM7329780 |
LT-HSC, StingKO-3 |
| GSM7329781 |
LT-HSC, WT-1-2nd |
| GSM7329782 |
LT-HSC, WT-2-2nd |
| GSM7329783 |
LT-HSC, WT-3-2nd |
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| Relations |
| BioProject |
PRJNA971897 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE232384_4LT_counts.txt.gz |
3.4 Mb |
(ftp)(http) |
TXT |
| GSE232384_TET2_project_counts.csv.gz |
2.2 Mb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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