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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 22, 2023 |
| Title |
The first transcriptomic atlas of the adult lacrimal gland reveals epithelial complexity and identifies novel progenitor cells in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The lacrimal gland (LG) secretes aqueous tears. Previous studies have provided insights into the cell lineage relationships during tissue morphogenesis. However, little is known about the cell types composing the adult LG and their progenitors. Using scRNA-seq, we established the first comprehensive cell atlas of the adult mouse LG to investigate cell hierarchy, their secretory repertoire and sex differences.
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| Overall design |
For each sample (1 Female and 2 Males), six dissected LGs of three animals aged of 2 months were combined and processed for scRNAseq analysis
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| Contributor(s) |
Delcroix V, Mauduit O, Lee HS, Ivanova A, Umazume T, Knox S, de Paiva CS, Dartt DA, Makarenkova HP |
| Citation(s) |
37408269 |
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| Submission date |
May 10, 2023 |
| Last update date |
Aug 10, 2023 |
| Contact name |
Helen Makarenkova |
| E-mail(s) |
[email protected]
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| Organization name |
The Scripps Research Institute
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| Department |
Molecular Medicine
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| Lab |
Makarenkova Lab
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| Street address |
10550 N Torrey Pines Rd, MB-218
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| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92037 |
| Country |
USA |
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| Platforms (2) |
| GPL21626 |
NextSeq 550 (Mus musculus) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA971124 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE232146_RAW.tar |
279.4 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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