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Series GSE22569 Query DataSets for GSE22569
Status Public on Dec 09, 2011
Title Gene expression in primate postnatal brain through lifespan - cerebellar cortex
Platform organism Homo sapiens
Sample organisms Macaca mulatta; Pan troglodytes; Homo sapiens
Experiment type Expression profiling by array
Summary We investigated molecular changes during human, chimpanzee, and rhesus macaque postnatal brain development at the transcriptome, proteome, and metabolome levels in two brain regions: the prefrontal cortex (PFC) that is involved in several human-specific cognitive processes, and the cerebellar cortex (CBC) that may be functionally more conserved. We find a nearly three-fold excess of human-specific gene expression changes in PFC compared to CBC. The most prominent human-specific mRNA expression pattern in the PFC is a developmental delay of approximately 5 years in the expression of genes associated with learning and memory, such as synaptic transmission and long-term potentiation. This pattern is supported by correlated changes in concentrations of proteins and the respective neurotransmitters and its magnitude is beyond the shift expected from the life-histories of the species. Mechanistically, it might be driven by change in timing of expression of four or more transcription factors. We speculate that delayed synaptic maturation in PFC may play a role in the emergence of human-specific cognitive abilities.

Keywords: Age series
 
Overall design Human, chimpanzee and rhesus macaque post-mortem brain samples from the cerebellar cortex were collected. The age ranges of the individuals in all three species covered the respective species' postnatal maturation period from infancy to old adulthood. RNA extracted from the dissected tissue was hybridized to Affymetrix® Human Gene 1.0 ST arrays.

CBC samples.
 
Contributor(s) Somel M, Liu X, Tang L, Yan Z, Guo S, Khaitovich P
Citation(s) 22162950, 22300767, 28724976
Submission date Jun 25, 2010
Last update date Jun 05, 2019
Contact name Mehmet Somel
E-mail(s) [email protected]
Phone +49-(0)341-3550-530
Fax +49-(0)341-3550-555
Organization name Max Planck Institute for Evolutionary Anthropology
Department Evolutionary Genetics
Street address Deutscher Platz 6
City Leipzig
ZIP/Postal code D-04103
Country Germany
 
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (62)
GSM560145 Human - cerebellar cortex - 14309 days old
GSM560146 Human - cerebellar cortex - 1630 days old
GSM560147 Human - cerebellar cortex - 19457 days old
This SubSeries is part of SuperSeries:
GSE22570 Gene expression in primate postnatal brain through lifespan
Relations
BioProject PRJNA129099

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22569_RAW.tar 228.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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