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| Status |
Public on Jan 29, 2024 |
| Title |
The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans [CUT&RUN] |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
SET-26, HCF-1, and HDA-1 are highly conserved chromatin factors with key roles in development and aging. Here we present mechanistic insights into how these factors regulate gene expression and modulate longevity in C. elegans. We show that SET-26 and HCF-1 cooperate to regulate a common set of genes, and both antagonize the histone deacetylase HDA-1 to limit longevity. We propose a model in which SET-26 recruits HCF-1 to chromatin in somatic cells, where they stabilize each other at the promoters of a subset of genes, particularly mitochondrial function genes, and regulate their expression. HDA-1 opposes SET-26 and HCF-1 on the regulation of a subset of their common target genes and in longevity. Our findings suggest that SET-26, HCF-1, and HDA-1 comprise a mechanism to fine-tune gene expression and longevity and likely have important implications for the mechanistic understanding of how these factors function in diverse organisms, particularly in aging biology.
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| Overall design |
CUT&RUN chromatin binding profiles of C. elegans proteins SET-26, HCF-1, and HDA-1 at day 1 of adulthood in somatic-only or whole worm samples, in set-26(tm2467) or hcf-1(pk924) mutant backgrounds. Profiles were obtained using CRISPR knock-in strains for each factor. Two replicates are included for each experiment, and normalization tracks (either antibody background or H3 immunoprecipitated in parallel) are included for each experiment.
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| Contributor(s) |
Emerson FJ, Lee S |
| Citation(s) |
38485937 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 AG024425 |
Genetic and Epigenetic Determinants of Longevity |
Cornell University |
Siu Sylvia Lee |
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| |
| Submission date |
Jan 30, 2023 |
| Last update date |
Mar 20, 2024 |
| Contact name |
Siu Sylvia Lee |
| E-mail(s) |
[email protected]
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| Organization name |
Cornell University
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| Street address |
520 Campus road
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| City |
Ithaca |
| State/province |
NY |
| ZIP/Postal code |
14850 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19757 |
Illumina NextSeq 500 (Caenorhabditis elegans) |
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| Samples (83)
|
| GSM7011391 |
Somatic SET-26 binding profile, germline-less glp-1(e2141) background, rep 1 |
| GSM7011392 |
Somatic SET-26 binding profile, germline-less glp-1(e2141) background, rep 2 |
| GSM7011393 |
Somatic HCF-1 binding profile, germline-less glp-1(e2141) background, rep 1 |
| GSM7011394 |
Somatic HCF-1 binding profile, germline-less glp-1(e2141) background, rep 2 |
| GSM7011395 |
H3 profile, normalization for somatic HCF-1 binding, germline-less glp-1(e2141) background, rep1 |
| GSM7011396 |
H3 profile, normalization for somatic HCF-1 profile, germline-less glp-1(e2141) background, rep2 |
| GSM7011397 |
Somatic HCF-1 binding profile in set-26(tm2467) mutant, germline-less glp-1(e2141) background, rep1 |
| GSM7011398 |
Somatic HCF-1 binding profile in set-26(tm2467) mutant, germline-less glp-1(e2141) background, rep2 |
| GSM7011399 |
H3 profile, normalization for somatic HCF-1 profile in set-26(tm2467) mutant, germline-less glp-1(e2141) backgrnd, rep1 |
| GSM7011400 |
H3 profile, normalization for somatic HCF-1 profile in set-26(tm2467) mutant, germline-less glp-1(e2141) backgrnd, rep2 |
| GSM7011401 |
Somatic HDA-1 binding profile, germline-less glp-1(e2141) background, rep 1 |
| GSM7011402 |
Somatic HDA-1 binding profile, germline-less glp-1(e2141) background, rep 2 |
| GSM7011403 |
Antibody background, HA, germline-less glp-1(e2141) background, rep 1 |
| GSM7011404 |
Antibody background, HA, germline-less glp-1(e2141) background, rep 2 |
| GSM7011405 |
Antibody background, FLAG, germline-less glp-1(e2141) background, rep 1 |
| GSM7011406 |
Antibody background , FLAG, germline-less glp-1(e2141) background, rep 2 |
| GSM7011407 |
Whole worm SET-26 binding profile, rep 1 |
| GSM7011408 |
Whole worm SET-26 binding profile, rep 2 |
| GSM7011409 |
Whole worm HCF-1 binding profile, rep 1 |
| GSM7011410 |
Whole worm HCF-1 binding profile, rep 2 |
| GSM7011411 |
Whole worm HDA-1 binding profile, rep 1 |
| GSM7011412 |
Whole worm HDA-1 binding profile, rep 2 |
| GSM7011413 |
Antibody background, HA, whole worm background, rep 1 for SET-26 profile |
| GSM7011414 |
Antibody background, HA, whole worm background, rep 1 for HDA-1 profile |
| GSM7011415 |
Antibody background, HA, whole worm background, rep 2 |
| GSM7011416 |
Antibody background, FLAG, whole worm background, rep 1 |
| GSM7011417 |
Antibody background, FLAG, whole worm background, rep 2 |
| GSM7011418 |
Somatic HCF-1 binding profile, germline-less glp-1 RNAi, rep 1 |
| GSM7011419 |
Somatic HCF-1 binding profile, germline-less glp-1 RNAi, rep 2 |
| GSM7011420 |
H3 profile, normalization for somatic HCF-1 binding, germline-less glp-1 RNAi, rep1 |
| GSM7011421 |
H3 profile, normalization for somatic HCF-1 binding, germline-less glp-1 RNAi, rep2 |
| GSM7011422 |
Somatic HCF-1 binding profile in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011423 |
Somatic HCF-1 binding profile in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011424 |
H3 profile, normalization for somatic HCF-1 binding in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011425 |
H3 profile, normalization for somatic HCF-1 binding in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011426 |
Whole worm HCF-1 binding profile, L4440, rep1 |
| GSM7011427 |
Whole worm HCF-1 binding profile, L4440, rep2 |
| GSM7011428 |
H3 profile, normalization for whole worm HCF-1 binding profile, L4440, rep1 |
| GSM7011429 |
H3 profile, normalization for whole worm HCF-1 binding profile, L4440, rep2 |
| GSM7011430 |
Whole worm HCF-1 binding profile in set-26(tm2467) mutant, L4440, rep1 |
| GSM7011431 |
Whole worm HCF-1 binding profile in set-26(tm2467) mutant, L4440, rep2 |
| GSM7011432 |
H3 profile, normalization for whole worm HCF-1 binding profile in set-26(tm2467) mutant, L4440, rep1 |
| GSM7011433 |
H3 profile, normalization for whole worm HCF-1 binding profile in set-26(tm2467) mutant, L4440, rep2 |
| GSM7011434 |
Somatic SET-26 binding profile, germline-less glp-1 RNAi, rep1 |
| GSM7011435 |
Somatic SET-26 binding profile, germline-less glp-1 RNAi, rep2 |
| GSM7011436 |
H3 profile, normalization for somatic SET-26 binding, germline-less glp-1 RNAi, rep1 |
| GSM7011437 |
H3 profile, normalization for somatic SET-26 binding, germline-less glp-1 RNAi, rep2 |
| GSM7011438 |
Somatic SET-26 binding profile in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011439 |
Somatic SET-26 binding profile in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011440 |
H3 profile, normalization for somatic SET-26 binding in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011441 |
H3 profile, normalization for somatic SET-26 binding in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011442 |
Whole worm SET-26 binding profile, L4440, rep1 |
| GSM7011443 |
Whole worm SET-26 binding profile, L4440, rep2 |
| GSM7011444 |
H3 profile, normalization for whole worm SET-26 binding, L4440, rep1 |
| GSM7011445 |
H3 profile, normalization for whole worm SET-26 binding, L4440, rep2 |
| GSM7011446 |
Whole worm SET-26 binding profile in hcf-1(pk924) mutant, L4440, rep1 |
| GSM7011447 |
Whole worm SET-26 binding profile in hcf-1(pk924) mutant, L4440, rep2 |
| GSM7011448 |
H3 profile, normalization for whole worm SET-26 binding in hcf-1(pk924) mutant, L4440, rep1 |
| GSM7011449 |
H3 profile, normalization for whole worm SET-26 binding in hcf-1(pk924) mutant, L4440, rep2 |
| GSM7011450 |
Somatic HDA-1 binding profile, germline-less glp-1 RNAi, rep1 |
| GSM7011451 |
Somatic HDA-1 binding profile, germline-less glp-1 RNAi, rep2 |
| GSM7011452 |
H3 profile, normalization for somatic HDA-1 binding, germline-less glp-1 RNAi, rep1 |
| GSM7011453 |
H3 profile, normalization for somatic HDA-1 binding, germline-less glp-1 RNAi, rep2 |
| GSM7011454 |
Somatic HDA-1 binding profile in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011455 |
Somatic HDA-1 binding profile in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011456 |
H3 profile, normalization for somatic HDA-1 binding in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011457 |
H3 profile, normalization for somatic HDA-1 binding in set-26(tm2467) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011458 |
Somatic HDA-1 binding profile in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011459 |
Somatic HDA-1 binding profile in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011460 |
H3 profile, normalization for somatic HDA-1 binding in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep1 |
| GSM7011461 |
H3 profile, normalization for somatic HDA-1 binding in hcf-1(pk924) mutant, germline-less glp-1 RNAi, rep2 |
| GSM7011462 |
Whole worm HDA-1 binding profile, L4440, rep1 |
| GSM7011463 |
Whole worm HDA-1 binding profile, L4440, rep2 |
| GSM7011464 |
H3 profile, normalization for whole worm HDA-1 binding profile, L4440, rep1 |
| GSM7011465 |
H3 profile, normalization for whole worm HDA-1 binding profile, L4440, rep2 |
| GSM7011466 |
Whole worm HDA-1 binding profile in set-26(tm2467) mutants, L4440, rep1 |
| GSM7011467 |
Whole worm HDA-1 binding profile in set-26(tm2467) mutants, L4440, rep2 |
| GSM7011468 |
H3 profile, normalization for whole worm HDA-1 binding profile in set-26(tm2467) mutants, L4440, rep1 |
| GSM7011469 |
H3 profile, normalization for whole worm HDA-1 binding profile in set-26(tm2467) mutants, L4440, rep2 |
| GSM7011470 |
Whole worm HDA-1 binding profile in hcf-1(pk924) mutants, L4440, rep1 |
| GSM7011471 |
Whole worm HDA-1 binding profile in hcf-1(pk924) mutants, L4440, rep2 |
| GSM7011472 |
H3 profile, normalization for whole worm HDA-1 binding profile in hcf-1(pk924) mutants, L4440, rep1 |
| GSM7011473 |
H3 profile, normalization for whole worm HDA-1 binding profile in hcf-1(pk924) mutants, L4440, rep2 |
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| This SubSeries is part of SuperSeries: |
| GSE224078 |
The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans |
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| Relations |
| BioProject |
PRJNA929523 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE224076_HCF-1.vs.H3_L4440_MergedReps.bigwig |
38.4 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HCF-1.vs.H3_L4440_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
259.4 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HCF-1.vs.H3_L4440_MergedReps_narrow_peaks_peaks.txt.gz |
299.9 Kb |
(ftp)(http) |
TXT |
| GSE224076_HCF-1.vs.H3_glp-1RNAi_MergedReps.bigwig |
38.4 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HCF-1.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
392.5 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HCF-1.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.txt.gz |
458.3 Kb |
(ftp)(http) |
TXT |
| GSE224076_HCF-1.vs.H3_glp-1mut_OP50_MergedReps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HCF-1.vs.H3_glp-1mut_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
496.9 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HCF-1.vs.H3_glp-1mut_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
578.3 Kb |
(ftp)(http) |
TXT |
| GSE224076_HCF-1.vs.antibodybackground_wildtype_OP50_MergedReps.bigwig |
38.6 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HCF-1.vs.antibodybackground_wildtype_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
265.6 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HCF-1.vs.antibodybackground_wildtype_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
316.0 Kb |
(ftp)(http) |
TXT |
| GSE224076_HCF-1_somatic.vs.antibodybackground_glp-1_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
419.9 Kb |
(ftp)(http) |
TXT |
| GSE224076_HCF-1_somatic.vs.antibodybackground_glp1_OP50_MergedReps.bigwig |
38.6 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HCF-1_somatic.vs.antibodybackground_glp1_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
356.9 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HDA-1.vs.H3_L4440_mergedreps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HDA-1.vs.H3_L4440_mergedreps_narrow_peaks_peaks.narrowPeak.gz |
246.7 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HDA-1.vs.H3_L4440_mergedreps_narrow_peaks_peaks.txt.gz |
291.4 Kb |
(ftp)(http) |
TXT |
| GSE224076_HDA-1.vs.H3_glp-1RNAi_mergedreps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HDA-1.vs.H3_glp-1RNAi_mergedreps_narrow_peaks_peaks.narrowPeak.gz |
420.4 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HDA-1.vs.H3_glp-1RNAi_mergedreps_narrow_peaks_peaks.txt.gz |
483.8 Kb |
(ftp)(http) |
TXT |
| GSE224076_HDA-1.vs.antibodybackground_wildtype_OP50_MergedReps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HDA-1.vs.antibodybackground_wildtype_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
226.5 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HDA-1.vs.antibodybackground_wildtype_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
263.7 Kb |
(ftp)(http) |
TXT |
| GSE224076_HDA-1_somatic.vs.antibodybackground_glp-1_OP50_MergedReps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_HDA-1_somatic.vs.antibodybackground_glp-1_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
419.5 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_HDA-1_somatic.vs.antibodybackground_glp-1_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
493.0 Kb |
(ftp)(http) |
TXT |
| GSE224076_SET-26.vs.H3_L4440_MergedReps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_SET-26.vs.H3_L4440_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
431.7 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_SET-26.vs.H3_L4440_MergedReps_narrow_peaks_peaks.txt.gz |
496.9 Kb |
(ftp)(http) |
TXT |
| GSE224076_SET-26.vs.H3_glp-1RNAi_MergedReps.bigwig |
38.5 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_SET-26.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
545.0 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_SET-26.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.txt.gz |
625.0 Kb |
(ftp)(http) |
TXT |
| GSE224076_SET-26.vs.antibodybackground_wildtype_OP50_MergedReps.bigwig |
38.5 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_SET-26.vs.antibodybackground_wildtype_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
549.8 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_SET-26.vs.antibodybackground_wildtype_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
629.5 Kb |
(ftp)(http) |
TXT |
| GSE224076_SET-26_somatic.vs.antibodybackground_glp-1_OP50_MergedReps.bigwig |
38.6 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_SET-26_somatic.vs.antibodybackground_glp-1_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
519.6 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_SET-26_somatic.vs.antibodybackground_glp-1_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
611.7 Kb |
(ftp)(http) |
TXT |
| GSE224076_hcf-1mutant_HDA-1.vs.H3_L4440_mergedreps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_hcf-1mutant_HDA-1.vs.H3_L4440_mergedreps_narrow_peaks_peaks.narrowPeak.gz |
227.7 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_hcf-1mutant_HDA-1.vs.H3_L4440_mergedreps_narrow_peaks_peaks.txt.gz |
268.8 Kb |
(ftp)(http) |
TXT |
| GSE224076_hcf-1mutant_HDA-1.vs.H3_glp-1RNAi_mergedreps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_hcf-1mutant_HDA-1.vs.H3_glp-1RNAi_mergedreps_narrow_peaks_peaks.narrowPeak.gz |
321.9 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_hcf-1mutant_HDA-1.vs.H3_glp-1RNAi_mergedreps_narrow_peaks_peaks.txt.gz |
372.9 Kb |
(ftp)(http) |
TXT |
| GSE224076_hcf-1mutant_SET-26.vs.H3_L4440_MergedReps.bigwig |
38.6 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_hcf-1mutant_SET-26.vs.H3_L4440_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
464.8 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_hcf-1mutant_SET-26.vs.H3_L4440_MergedReps_narrow_peaks_peaks.txt.gz |
534.6 Kb |
(ftp)(http) |
TXT |
| GSE224076_hcf-1mutant_SET-26.vs.H3_glp-1RNAi_MergedReps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_hcf-1mutant_SET-26.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
447.5 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_hcf-1mutant_SET-26.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.txt.gz |
525.8 Kb |
(ftp)(http) |
TXT |
| GSE224076_set-26mutant_HCF-1.vs.H3_L4440_MergedReps.bigwig |
38.5 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_set-26mutant_HCF-1.vs.H3_L4440_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
119.9 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_set-26mutant_HCF-1.vs.H3_L4440_MergedReps_narrow_peaks_peaks.txt.gz |
141.4 Kb |
(ftp)(http) |
TXT |
| GSE224076_set-26mutant_HCF-1.vs.H3_glp-1RNAi_MergedReps.bigwig |
38.5 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_set-26mutant_HCF-1.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
41.5 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_set-26mutant_HCF-1.vs.H3_glp-1RNAi_MergedReps_narrow_peaks_peaks.txt.gz |
48.9 Kb |
(ftp)(http) |
TXT |
| GSE224076_set-26mutant_HCF-1.vs.H3_glp-1mut_OP50_MergedReps.bigwig |
38.8 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_set-26mutant_HCF-1.vs.H3_glp-1mut_OP50_MergedReps_narrow_peaks_peaks.narrowPeak.gz |
159.0 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_set-26mutant_HCF-1.vs.H3_glp-1mut_OP50_MergedReps_narrow_peaks_peaks.txt.gz |
188.7 Kb |
(ftp)(http) |
TXT |
| GSE224076_set-26mutant_HDA-1.vs.H3_L4440_mergedreps.bigwig |
38.7 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_set-26mutant_HDA-1.vs.H3_L4440_mergedreps_narrow_peaks_peaks.narrowPeak.gz |
107.4 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_set-26mutant_HDA-1.vs.H3_L4440_mergedreps_narrow_peaks_peaks.txt.gz |
127.0 Kb |
(ftp)(http) |
TXT |
| GSE224076_set-26mutant_HDA-1.vs.H3_glp-1RNAi_mergedreps.bigwig |
38.8 Mb |
(ftp)(http) |
BIGWIG |
| GSE224076_set-26mutant_HDA-1.vs.H3_glp-1RNAi_mergedreps_narrow_peaks_peaks.narrowPeak.gz |
297.1 Kb |
(ftp)(http) |
NARROWPEAK |
| GSE224076_set-26mutant_HDA-1.vs.H3_glp-1RNAi_mergedreps_narrow_peaks_peaks.txt.gz |
343.3 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
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