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| Status |
Public on May 30, 2023 |
| Title |
Transcriptomic analysis of Notch (N) induced [NΔecd] Drosophila larval primary CNS tumours vs N allograft tumours in w1118 host flies |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The goal of this project was to compare NGS derived transciptional profiles of primary larval CNS tumours and allograft tumours from two stages (first-T0 and forth-T3) in Drosophila that are induced by overactivation of N pathway in order to decipher if N regulates similar or different sets of genes as primary hypeplasias transition to malignant tumours. The results of this study show that overactivation of N negatively regulates genes related to neuronal differentiation processes genes as N hyperplasias become more malignant and that genes related to stress, metabolsim and immunity are upregulated
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| Overall design |
mRNA profiles from FACS sorted, GFP positive Drosophila larval CNS N tumours (N FACS) vs the first (T0) allograft N tumours (N T0) vs the fourth (T3) serial allograft N tumours (N T3)
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| Web link |
https://www.pnas.org/doi/10.1073/pnas.2221601120#supplementary-materials
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| Contributor(s) |
Zacharioudaki E, Delidakis C, Voutyraki C, Theodorou V |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Nov 30, 2022 |
| Last update date |
Sep 04, 2023 |
| Contact name |
Christos Delidakis |
| E-mail(s) |
[email protected]
|
| Organization name |
FORTH-IMBB
|
| Street address |
100 N Plastira St
|
| City |
Heraklion |
| ZIP/Postal code |
70013 |
| Country |
Greece |
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| Platforms (1) |
| GPL19132 |
Illumina NextSeq 500 (Drosophila melanogaster) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA906978 |
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