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| Status |
Public on Dec 22, 2022 |
| Title |
Single-nucleus transcriptomic profiling of multiple organs from rhesus macaque model with SARS-CoV-2 infection |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Here we profiled about 77000 single-nucleus transcriptomes of lung, liver, kidney, and cerebral cortex from rhesus macaques infected with SARS-CoV-2. Our work of multi-organ single-nucleus transcriptomic survey of SARS-CoV-2 infected animal model expanded our understanding of disease features and antiviral immune defects caused by the novel coronavirus at cellular and molecular level, which may facilitate the development of potential therapeutic intervention for COVID-19.
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| Overall design |
Single-nucleus RNA-seq with lung, liver, kidney, cerebral cortex from two infected macaques as well as one or two healthy control. 10X Genomics platform was applied.
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| Contributor(s) |
Ma Q, Song T, Liu Z, Ma W, Wu Q, Yao Y, Zheng Y, Wang X |
| Citation(s) |
36349357 |
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| Submission date |
Nov 07, 2022 |
| Last update date |
Dec 25, 2022 |
| Contact name |
Qiang Ma |
| E-mail(s) |
[email protected]
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| Organization name |
Institute of Biophysics, Chinese Academy of Sciences
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| Street address |
Datun Road, #15
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| City |
Beijing |
| ZIP/Postal code |
100101 |
| Country |
China |
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| Platforms (1) |
| GPL27943 |
Illumina NovaSeq 6000 (Macaca mulatta) |
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| Samples (15)
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| GSM6720286 |
healthy, cerebrum, ctrl1 |
| GSM6720287 |
healthy, cerebrum, ctrl2 |
| GSM6720288 |
infected, lung, female, rep1 |
| GSM6720289 |
infected, lung, female, rep2 |
| GSM6720290 |
infected, liver, female |
| GSM6720291 |
infected, kidney, female |
| GSM6720292 |
infected, cerebrum, female |
| GSM6720293 |
infected, lung, male, rep1 |
| GSM6720294 |
infected, lung, male, rep2 |
| GSM6720295 |
infected, liver, male |
| GSM6720296 |
infected, kidney, male |
| GSM6720297 |
infected, cerebrum, male |
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| Relations |
| BioProject |
PRJNA899099 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE217483_Macaca_global_integration.h5ad.gz |
280.4 Mb |
(ftp)(http) |
H5AD |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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