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| Status |
Public on Oct 05, 2023 |
| Title |
Effect of EZH2 and BET bromodomain inhibition, alone and combined, on NUT carcinoma gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To determine mechanisms of synergy between EZH2 and BRD4-NUT, we treated NUT carcinoma cell lines with EZH2 inhibitor, tazemetostat, and/or BET bromodomain inhibitors (ABBV075 pan-BET inhibitor or ABBV744 BD2-selective inhibitor). We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different NUT carcinoma cell lines at two time points, 6h and 96h.
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| |
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for PER-403 and 10-15 NUT carcinoma cells treated with ABBV-744 or ABBV075 alone for 6h, tazemetostat alone for 96h, or tazemetostat combined with ABBV075 for 96h.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/37747726/
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| |
|
| Contributor(s) |
French CA, Huang D |
| Citation(s) |
37747726 |
| |
| Submission date |
Jul 21, 2022 |
| Last update date |
Jan 04, 2024 |
| Contact name |
Chris A French |
| E-mail(s) |
[email protected]
|
| Phone |
6175254415
|
| Organization name |
BWH
|
| Department |
Pathology
|
| Street address |
75 francis st.
|
| City |
boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (24)
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| Relations |
| BioProject |
PRJNA860981 |
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