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| Status |
Public on Nov 23, 2022 |
| Title |
Articular Fibrocartilage-Targeted Therapy by Microtubule Stabilization |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the fibrotic effect on BMSCs by CTGF and TGFβ1 treatment, and the anti-fibrotic effect of docetaxel on fibrotic chondrocytes. We established BMSCs primary culture and treated CTGF and TGFβ1, then treated by docetaxel.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for control Bone marrow-mesenchymal stem cells (BMSCs) and fibrotic BMSCs (treated with CTGF and TGF-β1), induced fibrotic-chondrocytes (iFCs)and iFCs treated with docetaxel
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| |
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| Contributor(s) |
Li J, Jiang H, Lv Z, Shi D |
| Citation(s) |
36399569 |
| |
| Submission date |
Jun 29, 2022 |
| Last update date |
Nov 23, 2022 |
| Contact name |
Jiawei Li |
| E-mail(s) |
[email protected]
|
| Organization name |
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing
|
| Department |
State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery
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| Street address |
Zhongshan road No.321
|
| City |
Nanjing |
| State/province |
Jiangsu |
| ZIP/Postal code |
210008 |
| Country |
China |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA853927 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE207148_BF_DvsBF_C_GOenrich_significant.txt.gz |
2.0 Kb |
(ftp)(http) |
TXT |
| GSE207148_BF_DvsBF_C_KEGGenrich_significant.txt.gz |
4.5 Kb |
(ftp)(http) |
TXT |
| GSE207148_BF_DvsBF_C_deg.txt.gz |
2.2 Mb |
(ftp)(http) |
TXT |
| GSE207148_BF_DvsBF_C_ppi.txt.gz |
10.4 Kb |
(ftp)(http) |
TXT |
| GSE207148_BMSC_CTvsBMSC_C_GOenrich_significant.txt.gz |
3.7 Kb |
(ftp)(http) |
TXT |
| GSE207148_BMSC_CTvsBMSC_C_KEGGenrich_significant.txt.gz |
6.9 Kb |
(ftp)(http) |
TXT |
| GSE207148_BMSC_CTvsBMSC_C_deg.txt.gz |
2.2 Mb |
(ftp)(http) |
TXT |
| GSE207148_BMSC_CTvsBMSC_C_ppi.txt.gz |
280.3 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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