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| Status |
Public on Apr 24, 2024 |
| Title |
Effect of cardiomyocyte-specific deletion of Gch1 on gene expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the physiological role of BH4 in cardiac function, we developed mice with cardiomyocyte-specific deletion of (cm)Gch1, the gene that encodes for GTPCH, which responsible for de novo synthesis of BH4.
We performed RNA sequencing in heart tissues from cmGch1 KO and WT mice.
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| |
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for cmGch1 KO and WT mice
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| |
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| Contributor(s) |
Chu S, Wright B, Miossec M, Lockstone H, Douglas G, Channon K |
| Citation(s) |
37184360 |
| |
| Submission date |
Jun 14, 2022 |
| Last update date |
Apr 24, 2024 |
| Contact name |
Sandy Chu |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Oxford
|
| Street address |
Wellcome Trust Centre for Human Genetics, Roosevelt Drive
|
| City |
Oxford |
| ZIP/Postal code |
OX3 7BN |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA848993 |
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