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| Status |
Public on Aug 03, 2022 |
| Title |
Effect of deletion of Irf3, Irf7 or Irf9 on gene expression in sgScd2 Th1 cells. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the role of the IRF family in the regulation of interferon stimulated genes, we conducted CRISPR/Cas9 mediated genome editing of Irf3, Irf7 or Irf9 in sgScd2 Th1 cells.
We then performed gene expression profiling analysis using data obtained from RNA-seq of control, sgScd2, sgScd2/sgIrf3, sgScd2/sgIrf7 or sgScd2/sgIrf9 Th1 cells.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for Th1 cells and its KO derivatives (sgScd2, sgScd2/sgIrf3, sgScd2/sgIrf7 and sgScd2/sgIrf9 Th1 cells).
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| Contributor(s) |
Kanno T, Miyako K, Nakajima T, Yokoyama S, Sasamoto S, Asou HK, Ohara O, Nakayama T, Endo Y |
| Citation(s) |
36059459 |
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| Submission date |
Apr 11, 2022 |
| Last update date |
Sep 15, 2022 |
| Contact name |
Toshio Kanno |
| E-mail(s) |
[email protected]
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| Organization name |
KAZUSA DNA Research Institute
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| Street address |
2-6-7 Kazusa-kamatari
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| City |
Kisarazu |
| State/province |
Chiba |
| ZIP/Postal code |
292-0818 |
| Country |
Japan |
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| Platforms (2) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
| GPL30172 |
NextSeq 2000 (Mus musculus) |
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| Samples (25)
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| Relations |
| BioProject |
PRJNA825571 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE200636_RNA-seq_Expression.txt.gz |
1.1 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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