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| Status |
Public on Apr 11, 2023 |
| Title |
Aberrant activation of canonical Notch1 signaling in the mouse prostate drives epithelialcell proliferation and induces prostatic hyperplasiaby increasing androgen receptor sensitivity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To investigate the regulatory role of Notch1 signaling pathway in mouse prostate growth and development, we constructed mice with prostate-specific overactivation of Notch1 intracellular domain N1ICD, in which Notch1 signaling was overactivated in prostate epithelial cells. We then analyzed gene expression profiles in the prostates of overexpressed and normal Notch1 mice.
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| Overall design |
Comparative analysis of gene expression profiles of RNA-SEQ data from two types of mouse anterior prostatic cells.
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| Contributor(s) |
Su R |
| Citation(s) |
38538986 |
| |
| Submission date |
Apr 11, 2022 |
| Last update date |
Apr 04, 2024 |
| Contact name |
Ren-Wei Su |
| E-mail(s) |
[email protected]
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| Organization name |
South China Agricultural University
|
| Department |
Histology and Embryology
|
| Lab |
Su' Lab
|
| Street address |
483 Wushan Road
|
| City |
Guangzhou |
| State/province |
Guangdong |
| ZIP/Postal code |
510642 |
| Country |
China |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA825375 |
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