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Series GSE196944 Query DataSets for GSE196944
Status Public on Feb 18, 2022
Title A transcriptomic study reveals that fish vibriosis due to the zoonotic pathogen Vibrio vulnificus is an acute inflammatory disease.
Organism Anguilla anguilla
Experiment type Expression profiling by array
Summary Vibrio vulnificus is a marine zoonotic pathogen associated with fish farms that is considered a biomarker of climate change. Zoonotic strains trigger a rapid death of their susceptible hosts (fish or humans) by septicemia that has been linked to a cytokine storm in mice. A toxin called RtxA1 produced by the bacteria might play an important role in bacterial invasion and subsequent death by septic shock since animals infected with a mutant deficient in rtxA1 suffer from septicemia but do not die. The aim of this study was to globally analyze the early eel immune response in blood against V. vulnificus, as well as the role of the RtxA1 toxin on this interaction.
 
Overall design We used the eel immersion infection model and then analyzed the transcriptome in RBCs, white BCs, and whole blood using an eel-specific microarray platform.
 
Contributor(s) Hernández-Cabanyero C, Sanjuán E, Reyes-López FE, Vallejos-Vidal E, Tort L, Amaro C
Citation(s) 35432241
Submission date Feb 17, 2022
Last update date Apr 20, 2022
Contact name Carmen Amaro
E-mail(s) [email protected]
Organization name University of Valencia
Department Microbiology and Ecology
Street address Dr. Moliner, 50
City Burjassot
State/province Valencia
ZIP/Postal code 46100
Country Spain
 
Platforms (1)
GPL16775 Agilent-042990 Eel SSA microarray V1.0
Samples (63)
GSM5905378 Control_Blood_0hpi_rep1 [CKS_1]
GSM5905379 Control_Blood_0hpi_rep2 [CKS_2]
GSM5905380 Control_Blood_0hpi_rep3 [CKS_3]
Relations
BioProject PRJNA807932

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE196944_RAW.tar 142.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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