 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Feb 03, 2023 |
| Title |
LySR, a lysosomal surveillance response that extends healthspan [Exp1] |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Lysosomes are cytoplasmic organelles that are central for the degradation of macromolecules to maintain cellular homeostasis and health. Here, we discovered an adaptive lysosomal transcriptional response that we termed the lysosomal stress response (LySR). Typified by the induction of a large group of transcripts involved in lysosomal function and proteolysis, the LySR can be triggered by silencing of specific vacuolar H+-ATPase subunits in Caenorhabditis elegans. Notably, LySR activation enhances the clearance of protein aggregates in worm models of Alzheimer's and Huntington’s disease and amyotrophic lateral sclerosis, thereby boosting fitness and extending lifespan, a response that is controlled by the GATA transcription factor, ELT-2. Activating the LySR pathway may therefore represent an attractive mechanism to reduce protein aggregation and, as such, extend healthspan.
|
| |
|
| Overall design |
Wild-type C. elegans fed with control, vha-6, vha-16, and vha-19 RNAi
|
| |
|
| Contributor(s) |
Li TY, Gao AW, Li X, Liu YJ, Lalou A, Wang Q, Lima T, Shong M, Auwerx J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Feb 03, 2022 |
| Last update date |
Apr 25, 2024 |
| Contact name |
Terytty Yang Li |
| E-mail(s) |
[email protected]
|
| Organization name |
EPFL
|
| Street address |
EPFL SV IBI-SV LISP AI 1145
|
| City |
Lausanne |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL25145 |
BGISEQ-500 (Caenorhabditis elegans) |
|
| Samples (12)
|
|
| This SubSeries is part of SuperSeries: |
| GSE196023 |
A lysosomal surveillance response that extends healthspan |
|
| Relations |
| BioProject |
PRJNA803027 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE196021_Processed_RNA-seq_data_Exp1_TYL.xlsx |
1.5 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...