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| Status |
Public on Oct 20, 2021 |
| Title |
Expression of CCRL2 inhibits tumor growth by concentrating chemerin and inhibiting neoangiogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
CCRL2 is a non-signaling G protein-coupled receptor for chemerin, a leukocyte chemoattractant and an adipokine. Graft of B16 melanoma or Lewis lung carcinoma (LLC) cell lines in CCRL2 KO mice results in delayed growth of the tumors.
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| Overall design |
mRNA profiles of LLC and B16 tumors (5 days following graft in the back of syngeneic C57BL/6 mice) in CCRL2 WT or KO mice were generated, in duplicate, using Illumina Hiseq1500.
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| Contributor(s) |
Delbany DA, Robert V, Dubois-Vedrenne I, Del Prete A, Vernimmen M, Radi A, Lefort A, Libert F, Wittamer V, Sozzani S, Parmentier M |
| Citation(s) |
34638484 |
| |
| Submission date |
Sep 10, 2021 |
| Last update date |
Oct 20, 2021 |
| Contact name |
Frederick Libert |
| E-mail(s) |
[email protected]
|
| Organization name |
ULB
|
| Department |
IRIBHM
|
| Lab |
C2-140
|
| Street address |
808 route de Lennik
|
| City |
Brussels |
| ZIP/Postal code |
B-1070 |
| Country |
Belgium |
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| Platforms (1) |
| GPL18480 |
Illumina HiSeq 1500 (Mus musculus) |
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| Samples (8)
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| GSM5573734 |
LLC tumor in CCRL2 WT mouse - replica 1 |
| GSM5573735 |
LLC tumor in CCRL2 WT mouse - replica 2 |
| GSM5573736 |
LLC tumor in CCRL2 KO mouse - replica 1 |
| GSM5573737 |
LLC tumor in CCRL2 KO mouse - replica 2 |
| GSM5573738 |
B16 tumor in CCRL2 WT mouse - replica 1 |
| GSM5573739 |
B16 tumor in CCRL2 WT mouse - replica 2 |
| GSM5573740 |
B16 tumor in CCRL2 KO mouse - replica 1 |
| GSM5573741 |
B16 tumor in CCRL2 KO mouse - replica 2 |
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| Relations |
| BioProject |
PRJNA762327 |
| SRA |
SRP336560 |
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