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| Status |
Public on Nov 03, 2022 |
| Title |
Elucidate the role of CD74 in gene transcription regulation by analyzing the genes up or down regulated after 8 hours of activation in human naive B cells. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
CD74 (invariant chain), expressed on B cells, is directly involved in shaping the B cell repertoire by regulating their survival in health and disease. Binding of its ligand, macrophage migration inhibitory factor (MIF), induces a cascade that results in CD74 intramembrane proteolysis, and the release of the CD74 intracellular domain (CD74-ICD). CD74-ICD translocates to the nucleus where it induces activation of transcription. In the current study, we characterize the transcription regulator activities of CD74 by analysing its ability to alter gene expression in mRNA levels.
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| |
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| Overall design |
Examination of the genes that are being up or down regulated after CD74 cell surface mulecule activation.
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| Contributor(s) |
Shachar I, David K |
| Citation(s) |
36323260 |
| |
| Submission date |
Aug 09, 2021 |
| Last update date |
Nov 03, 2022 |
| Contact name |
Idit Shachar |
| Organization name |
Weizmann Institute
|
| Street address |
234 Herzl Street
|
| City |
Rehovot |
| ZIP/Postal code |
POB 26 7610001 |
| Country |
Israel |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA753001 |
| SRA |
SRP331610 |
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