|
| Status |
Public on Apr 26, 2022 |
| Title |
Inhibition of pyrimidine biosynthesis targets protein translation in AML [ATAC-seq_MN-2] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Investigation of the chromatin accessibility in MN cells. Mice bearing MN tumors were treated with AG636 for 2 days. Leukemic stem cells (cKit high; CD11b low) from bone marrow and spleen were isolated. RNA sequencing and ATAC-seq were performed.
|
| |
|
| Overall design |
Genome binding/occupancy profiling of Vehicle- or AG636-treated MN AML cells by high-throughput sequencing.
|
| |
|
| Contributor(s) |
So J, Gruber E |
| Citation(s) |
35514210 |
| |
| Submission date |
Aug 08, 2021 |
| Last update date |
Jul 20, 2022 |
| Contact name |
Joan So |
| E-mail(s) |
[email protected]
|
| Organization name |
Peter MacCallum Cancer Centre
|
| Street address |
305 Grattan St
|
| City |
Melbourne |
| State/province |
Victoria |
| ZIP/Postal code |
3000 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (4)
|
|
| This SubSeries is part of SuperSeries: |
| GSE181666 |
Inhibition of pyrimidine biosynthesis targets protein translation in AML |
|
| Relations |
| BioProject |
PRJNA752899 |
| SRA |
SRP331538 |
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