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| Status |
Public on Aug 15, 2009 |
| Title |
Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
High-density lipoproteins (HDLs) protect pancreatic β cells against apoptosis. This property might be related to the increased risk to develop diabetes in patients with low HDL blood levels. However, the mechanisms by which HDLs protect β cells are poorly characterized. Here we use a transcriptomic approach to identify genes differentially modulated by HDLs in β cells subjected to apoptotic stimuli.
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| Overall design |
Tested conditions on beta-TC3 cells for 6h (in triplicates for each condition; GSK3 and GSK4 indicate two independent HDL preparations):
Complete Medium + Vehicle [V]
Complete Medium + HDL (prep. HDL GSK3 or HDL GSK4) [HDL]
Starvation medium + Vehicle [V.S]
Starvation medium + HDL (prep. HDL GSK3 or HDL GSK4) [HDL.S]
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| |
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| Contributor(s) |
Widmann C, Ghosh S |
| Citation(s) |
19574449 |
| |
| Submission date |
Aug 14, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Joan Stuart |
| E-mail(s) |
[email protected]
|
| Organization name |
GSK
|
| Street address |
5 Moore Drive
|
| City |
RTP |
| ZIP/Postal code |
27709 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA118595 |
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