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| Status |
Public on Jul 14, 2021 |
| Title |
Gene expression profiles analyzed using integrating RNA sequencing and microarray reveals increased inflammatory response, proliferation, and osteoclastogenesis in pigmented villonodular synovitis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pigmented villonodular synovitis (PVNS) is a rare condition that involves benign proliferation of the synovial tissue and is characterized by severe joint destruction and high recurrence even after surgical resection. However, poor understanding of the pathogenesis limitsitseffective therapy.
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| Overall design |
In this study, gene expression profiles of three patients with PVNS and three patients with osteoarthritis (OA) were analyzed using integrating RNA sequencing (RNA-seq) and microarray to investigate the PVNS transcriptome.
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| Contributor(s) |
Dai H, Zhang X |
| Citation(s) |
34248943 |
| |
| Submission date |
Jun 04, 2021 |
| Last update date |
Jul 16, 2021 |
| Contact name |
Dai Hui |
| E-mail(s) |
[email protected]
|
| Organization name |
Department of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Peking University
|
| Street address |
Xue Yuan Road 28, Haidian District
|
| City |
Beijing |
| ZIP/Postal code |
100191 |
| Country |
China |
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| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
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| Samples (6)
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| GSM5356821 |
Synovial tisssue from osteoarthritis joint [OA1A] |
| GSM5356822 |
Synovial tisssue from osteoarthritis joint [OAA] |
| GSM5356823 |
Synovial tisssue from osteoarthritis joint [zxA] |
| GSM5356824 |
Synovial tisssue from Pigmented villonodular synovitis joint [zxs140421A] |
| GSM5356825 |
Synovial tisssue from Pigmented villonodular synovitis joint [zxs140525A] |
| GSM5356826 |
Synovial tisssue from Pigmented villonodular synovitis joint [zxs140611A] |
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| Relations |
| BioProject |
PRJNA735031 |
| SRA |
SRP322624 |
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