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| Status |
Public on Mar 22, 2010 |
| Title |
Expression data from K5-IKKbeta transgenic mouse skin |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
IKKbeta is a subunit of the IkB kinase (IKK) complex required for NF-kB activation in response to pro-inflammatory signals. NF-kB regulates the expression of many genes involved in inflammation, immunity and apoptosis, and also controls cell proliferation and differentiation in different tissues; however, its function in skin physiopathology remains controversial. We here report the alterations caused by increased IKKbeta activity in basal cells of the skin of transgenic mice.
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| Overall design |
Transgenic mice which express the IKKbeta gene under the control of the keratin K5 regulatory elements were generated. We analyzed back skins from wildtype and transgenic animals. Each individual array has RNA from three different mice of the same genotype.
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| Contributor(s) |
Navarro M, Ramirez A |
| Citation(s) |
20200541 |
| |
| Submission date |
Aug 05, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Manuel Navarro |
| E-mail(s) |
[email protected]
|
| Organization name |
CIEMAT
|
| Department |
Molecular Oncology
|
| Street address |
Av. Complutense 40
|
| City |
Madrid |
| ZIP/Postal code |
28040 |
| Country |
Spain |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (4)
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| Relations |
| BioProject |
PRJNA118781 |
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