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| Status |
Public on Feb 01, 2010 |
| Title |
Gene Expression in Frontal Cortex in Major Depression and HIV |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Major depressive disorder (MDD) is a clinically defined entity with little understanding as to the underlying pathological substrate. Biologically, MDD is characterized by disruption of neurotransmitters, especially serotonin and noradrenaline, which are the main targets of antidepressants. We previously demonstrated significant reduction of glial cell number in the cingulate and dorsolateral prefrontal cortical regions. Unfortunately, individuals living with HIV still have very high rates of MDD, despite the fact that mortality rates have fallen sharply with effective antiretroviral treatment. It is possible that in this treatment era, living with chronic HIV infection may result in long-term neuropathological changes that predispose to MDD. For example, it is known that HIV is associated with a range of inflammatory pathologies, neuronal loss, and dendrite-synaptic damage. In HIV, these neurodegenerative changes have been linked to neurocognitive impairments, however it is also possible that these changes potentiate MDD.
In the current study, we sought to determine whether there are changes in gene expression in the MDD brain in the frontal cortex in HIV-context. We identify a large number of genes dysregulated at p<0.05 significance.
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| Overall design |
Retrospective gene expression analysis of autopsy brain tissue. Four HIV/MDD subjects are identified and age-matched HIV patients without neuropsychiatric conditions are compared as controls.
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| Contributor(s) |
Tatro ET, Salaria S, Chana G, Scott ER, Nguyen TB, Masliah E, Achim CL, Everall IP |
| Citation(s) |
20436668 |
| |
| Submission date |
Jul 30, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Erick T Tatro |
| E-mail(s) |
[email protected]
|
| Phone |
858-246-0653
|
| Fax |
858-534-4484
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| Organization name |
University of California San Diego
|
| Department |
Psychiatry
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| Lab |
Tatro
|
| Street address |
9500 Gilman Dr
|
| City |
La Jolla |
| State/province |
CA |
| ZIP/Postal code |
92093-0603 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE17491 |
Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain |
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| Relations |
| BioProject |
PRJNA123617 |
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