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Series GSE163774 Query DataSets for GSE163774
Status Public on Dec 01, 2022
Title profiling of histone modifications in SARS-CoV-2 infected cells
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Purpose: The goal of this study is to understand the response and pathology of the epigenome upon infection with SARS-CoV-2 in lung and heart tissues
Methods: AT2 and induced cardiomyocytes were infected (MOI 4) with SARS-CoV-2 or Mock infection control for 48 hours followed by chromatin immunoprecipitation and sequencing.
Results: global differences in hPTMs were observed upon infection related to SARS-CoV-2 histone mimicry
Conclusions: SARS-CoV-2 sucks
 
Overall design ChIP-seq profiling of hPTMs in AT2 and iCM cells upon infection
 
Contributor(s) Glastad KM, Berger S
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Dec 23, 2020
Last update date Dec 03, 2022
Contact name Karl Michael Glastad
E-mail(s) [email protected]
Organization name University of Pennsylvania
Department CDB
Lab Berger
Street address 3400 Civic Center Blvd, Bldg 421
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL21697 NextSeq 550 (Homo sapiens)
Samples (56)
GSM4986944 AT2 Mock infection replicate r1 ChIP of K27ac
GSM4986945 AT2 Mock infection replicate r2 ChIP of K27ac
GSM4986946 AT2 Mock infection replicate r3 ChIP of K27ac
Relations
BioProject PRJNA687511
SRA SRP299110

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE163774_RAW.tar 43.5 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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