|
| Status |
Public on Jun 28, 2021 |
| Title |
Host response to RhCMV/SIV immunization through subcutaneous and oral route |
| Organism |
Macaca mulatta |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Strain 68-1–derived Rhesus Cytomegalovirus (RhCMV) vectors expressing simian immunodeficiency virus (SIV) proteins (RhCMV/SIV) are able to elicit and maintain cellular immune responses that stringently control and subsequently clear a mucosal challenge with highly pathogenic SIV in 50-60% of vaccinated rhesus monkeys (RMs). Here, we utilize whole blood transcriptomic profiling to identify host responses correlated to RhCMV/SIV efficacy.
|
| |
|
| Overall design |
Longitudinal mRNA profiling of whole blood from rhesus macaques during immunization with RhCMV/SIV.
|
| |
|
| Citation(s) |
34228762, 36536032 |
| |
| Submission date |
Oct 30, 2020 |
| Last update date |
Jan 11, 2023 |
| Contact name |
Michael Gale, Jr |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Washington
|
| Department |
Immunology
|
| Street address |
750 Republican St. E360, Box 358059
|
| City |
Seattle |
| State/province |
Washington |
| ZIP/Postal code |
98109 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL21120 |
Illumina NextSeq 500 (Macaca mulatta) |
|
| Samples (403)
|
|
| Relations |
| BioProject |
PRJNA677978 |
| SRA |
SRP292387 |
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