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| Status |
Public on Oct 22, 2020 |
| Title |
Peripheral inflammation is associated with remote global gene expression changes in the brain |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Microarray analysis of whole brain RNA collected 48 hr after LPS (4mg/kg i.p.) injection
We induced systemic inflammation by injecting mice with LPS. We then performed global gene expression profiling of whole brain RNA and looked for genes that may be involved in behavioural changes.
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| Overall design |
Male C57BL6 mice were injected (i.p.) with 4mg/kg LPS (Escherichia coli serotype 055:B5) or PBS (n=3/group). Mice were euthanised 48 hours after injection and GeneChip Mouse Gene 1.0 ST Arrays (Affymetrix) were used for transcriptional analysis of whole brain RNA.
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| Contributor(s) |
Thomson CA, McColl A, Cavanagh J, Graham GJ |
| Citation(s) |
24708794 |
| |
| Submission date |
Oct 21, 2020 |
| Last update date |
Jan 21, 2021 |
| Contact name |
Jonathan Cavanagh |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Glasgow
|
| Department |
Immunology
|
| Street address |
120 University Place
|
| City |
Glasgow |
| ZIP/Postal code |
G12 0TA |
| Country |
United Kingdom |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| GSM4844287 |
PBS injected healthy control, biological rep 1 |
| GSM4844288 |
PBS injected healthy control, biological rep 2 |
| GSM4844289 |
PBS injected healthy control, biological rep 3 |
| GSM4844290 |
LPS injected healthy control, biological rep 1 |
| GSM4844291 |
LPS injected healthy control, biological rep 2 |
| GSM4844292 |
LPS injected healthy control, biological rep 3 |
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| Relations |
| BioProject |
PRJNA670446 |
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