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| Status |
Public on Jun 11, 2021 |
| Title |
To identify GCM1 novel target genes by chromatin immunoprecipitation-on-chip (ChIP-chip) analysis |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
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| Summary |
In this study, we performed chromatin immunoprecipitation-on-chip (ChIP-chip) analysis and identified the gene for high-temperature requirement protein A4 (HtrA4) as a GCM1 target gene, which encodes a serine protease facilitating cleavage of fibronectin and invasion of placental cells. Importantly, HtrA4 is immunolocalized in EVTs at the maternal-fetal interface, and its expression is decreased by hypoxia and in preeclampsia, a pregnancy complication associated with placental hypoxia and shallow trophoblast invasion.
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| Overall design |
Analysis of GCM1-binding sequences by ChIP-chip.
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| Contributor(s) |
Wang LJ, Lee YS, Chen H |
| Citation(s) |
22778138, 35338152 |
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| Submission date |
Oct 01, 2020 |
| Last update date |
Apr 27, 2022 |
| Contact name |
Yun-Shien Lee |
| E-mail(s) |
[email protected]
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| Organization name |
Ming Chuan Univ
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| Department |
Dept. Biotechnology
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| Lab |
GMRCL
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| Street address |
TauYau
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| City |
TauYau |
| State/province |
Taiwan |
| ZIP/Postal code |
115 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL5082 |
[Hs_PromPR] Affymetrix Human Promoter 1.0R Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA666914 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE158894_Log2Intensity.txt.gz |
83.5 Mb |
(ftp)(http) |
TXT |
| GSE158894_RAW.tar |
72.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data are available on Series record |
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