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| Status |
Public on May 12, 2020 |
| Title |
Gene expression patterns of tumor-infiltrating CD8 T cells according to the CD137 expression in human metastatic ovarian cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report the differences of gene expression pattern of tumor-infiltrating CD8 T cells between CD137 expressing cells and CD137 non-expressing cells in human metastatic ovarian cancer. Samples are obtained from 3 ovarian cancer patients, and we sorted CD137 expressing cells and CD137 non-expressing cells in CD39 expressing CD8 T cells for RNA sequencing. We found that even though the CD39 expression and PD-1 expression levels are similar, CD137 expressing cells showed more activated and less exhausted phenotypes than CD137 non-expressing cells.
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| Overall design |
Compare gene expression patterns between CD137 expressing CD39+ CD8 T cells and CD137 non-expressing CD39+ CD8 T cells. Control cells were CD39- CD8 T cells.
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| Contributor(s) |
Leem G, Park S |
| Citation missing |
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| |
| Submission date |
May 11, 2020 |
| Last update date |
May 13, 2020 |
| Contact name |
Galam Leem |
| E-mail(s) |
[email protected]
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| Organization name |
KAIST
|
| Lab |
LIID
|
| Street address |
291 Daehakro Yusunggu
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| City |
Daejeon |
| ZIP/Postal code |
34141 |
| Country |
South Korea |
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| Platforms (1) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA631736 |
| SRA |
SRP261127 |
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