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Series GSE15008 Query DataSets for GSE15008
Status Public on Feb 11, 2010
Title MicroRNA Expression Profile Reveals Important Clinical Tools for the Pathology of Lung Cancer
Platform organisms Homo sapiens; Mus musculus; Rattus norvegicus
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary We investigated whether the miRNA expression could distinguish lung cancers from normal tissues, examining 116 pairs of primary lung cancers with their corresponding adjacent normal lung tissues collected a minimum of 5 cm from the tumor. Our analysis identified a five microRNA classifier could distinguish malignant lung cancer lesions from adjacent normal tissues. SCLC could be distinguished from non small lung cancer by microRNAs profiling. Survival associations were examined with the SCC and adenocarcinoma subtypes. High hsa-miR-31 expression was associated with poor survival in SCC, and the association was confirmed in 20 independent SCC patients by qRT-PCR assays. Overall these findings may help advance the use of microRNA profiling in personalized diagnosis of lung cancers.
Key Words: microRNA; lung cancer; microarray; diagnosis; prognosis
 
Overall design cancer vs adjacent normal tissues
 
Citation(s) 21890451
Submission date Feb 26, 2009
Last update date Mar 21, 2012
Contact name wu jp
E-mail(s) [email protected]
Fax (86)-10-62773059
Organization name National Engineering Research Center
Street address 18 Life Science Parkway
City beijing
ZIP/Postal code 102206
Country China
 
Platforms (1)
GPL8176 National Engineering Research Center mammalian microRNA microarray
Samples (375)
GSM374978 Adjacent normal tissue from patient 200746-1
GSM374979 Adjacent normal tissue from patient 200746-2
GSM374980 Cancer tissue from patient 200746-1
Relations
BioProject PRJNA114723

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE15008_RAW.tar 9.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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