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| Status |
Public on Dec 01, 2020 |
| Title |
Identifying and overcoming a mechanism of resistance to Wee1 kinase inhibitor AZD1775 in high grade serous ovarian cancer cells (ES-2) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Treatment of Human high grade serous ovarian cancer cell line, ES-2, with WEE1 kinase inhibitor AZD1775
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| Overall design |
The experiment comprises 16 samples (MKG1-16) from ES-2 and ES-2 derived resistant clones: duplicate cultures of untreated ES-2 parent and ES-2 parent treated for 24 hours with 100nM AZD1775, triplicate cultures of four resistant clones maintained in AZD1775- two clones resistant to 1000nM AZD1775 and their progenitors resistant to 250nM AZD1775
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| Contributor(s) |
Melton DW, Gomez MK, Grimes GR |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 16, 2019 |
| Last update date |
Dec 04, 2020 |
| Contact name |
Graeme Richard Grimes |
| E-mail(s) |
[email protected]
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| Organization name |
University of Edinburgh, The Institute of Genetics and Cancer
|
| Department |
Human Genetics Unit
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| Lab |
Bioinformatics Analysis Core
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| Street address |
Western General Hospital, Crewe Road
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| City |
Edinburgh |
| ZIP/Postal code |
EH4 2XU |
| Country |
United Kingdom |
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| Platforms (1) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE142126 |
Identifying and overcoming a mechanism of resistance to Wee1 kinase inhibitor AZD1775 in high grade serous ovarian cancer cells |
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| Relations |
| BioProject |
PRJNA595945 |
| SRA |
SRP237788 |
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