|
| Status |
Public on Dec 01, 2020 |
| Title |
Identifying and overcoming a mechanism of resistance to Wee1 kinase inhibitor AZD1775 in high grade serous ovarian cancer cells (OVCAR8) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Treatment of Human high grade serous ovarian cancer cell line, OVCAR8, with WEE1 kinase inhibitor AZD1775
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| |
|
| Overall design |
12 samples (MKG101-112) from triplicate cultures of OVCAR8 parent treated with 100nM AZD1775 for 24 hours and three OVCAR8-derived clones resistant to 300nM AZD1775 and maintained under selection
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| |
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| Contributor(s) |
Melton DW, Gomez MK, Grimes GR |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 13, 2019 |
| Last update date |
Dec 04, 2020 |
| Contact name |
Graeme Richard Grimes |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Edinburgh, The Institute of Genetics and Cancer
|
| Department |
Human Genetics Unit
|
| Lab |
Bioinformatics Analysis Core
|
| Street address |
Western General Hospital, Crewe Road
|
| City |
Edinburgh |
| ZIP/Postal code |
EH4 2XU |
| Country |
United Kingdom |
| |
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| Platforms (1) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE142126 |
Identifying and overcoming a mechanism of resistance to Wee1 kinase inhibitor AZD1775 in high grade serous ovarian cancer cells |
|
| Relations |
| BioProject |
PRJNA595516 |
| SRA |
SRP237513 |
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