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| Status |
Public on Nov 26, 2019 |
| Title |
Transcriptomic analysis of ETV6/RUNX1 KO lymphoid cell line generated by CRISPR/Cas9 showed a distinct expression signature and a deregulation of its downstream signaling genes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The gene expression profile of E/R KO clones versus REH cells and controls clones, analysed by total RNA-sequencing, showed a total of 342 genes differentially expressed (q<0.05), 182 upregulated and 160 downregulated. The heatmap of the top50 of the most deregulated genes according to fold change (FC) values showed a distinct expression signature of E/R KO clones as compared with REH cells and control clones
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| Overall design |
Purpose: Analyse the gene expression profile of ETV6/RUNX1 KO clones versus REH cells and controls clones by total RNA-sequencing to elucidate the functional effects of fusion gene abrogation in ALL cells.
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| Contributor(s) |
Hernández Rivas JM |
| Citation(s) |
31952221 |
| |
| Submission date |
Nov 25, 2019 |
| Last update date |
Feb 25, 2020 |
| Contact name |
Adrian Montano |
| E-mail(s) |
[email protected]
|
| Organization name |
Cancer research center
|
| Street address |
Campus Miguel de Unamuno SN
|
| City |
Salamanca |
| ZIP/Postal code |
37007 |
| Country |
Spain |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA591607 |
| SRA |
SRP233213 |
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