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| Status |
Public on Jun 01, 2020 |
| Title |
β-catenin regulates FOXP2 transcriptional activity via multiple binding sites |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We observed different gene expression by overexpressing the transcription factor FOXP2 in U2OS cells compared to mock-transfected cells. Additionally, we found β-catenin as co-activator binding directly to FOXP2. Activation of Wnt signaling was changing the transcriptional activity of FOXP2. Other functional and regulatory elements were found within FOXP2 and were confirmed by RNA-Seq.
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| |
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| Overall design |
Determining gene expression differences by overexpressing an transcription factor (wildtype and mutant) in human osteosarcoma cells and additional activation of an Signaling pathway linked to the function of this transcription factor
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| |
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| Contributor(s) |
Richter G, Madl T |
| Citation(s) |
33284517 |
| |
| Submission date |
Oct 16, 2019 |
| Last update date |
Jul 08, 2021 |
| Contact name |
Gesa Richter |
| E-mail(s) |
[email protected]
|
| Organization name |
Medical University Graz
|
| Street address |
Neue Stiftingtalstrasse 6
|
| City |
Graz |
| ZIP/Postal code |
8010 |
| Country |
Austria |
| |
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| Platforms (1) |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA577855 |
| SRA |
SRP225889 |
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