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| Status |
Public on Apr 24, 2019 |
| Title |
Analysis of possible mechanisms behind functional recovery following neural progenitor cell transplantation into spinal cord injury. |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Long-term survival and integration of neural progenitor cells (NPCs) transplanted following spinal cord injury (SCI) have been observed. However, questions concerning the differentiation choice of NPCs, their mechanism of action and their contribution to functional recovery remains unanswered. Therefore, we investigated global transcriptomal changes in transplanted NPCs transplanted into SCI. We found that NPCs transplanted into SCI up-regulate genes related to nerve cell function and signaling and differentiation, and down-regulate genes related to cytokine signaling and apoptosis.
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| |
|
| Overall design |
Stem cells transplantation in spinal cord injury in rodents
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| |
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| Contributor(s) |
Sankavaram S, Hakim R, Frostell A, Covacu R, Neumann S, Svensson M, Brundin L |
| Citation(s) |
31031190 |
| |
| Submission date |
Jan 15, 2019 |
| Last update date |
Jun 19, 2019 |
| Contact name |
Mikael Svensson |
| E-mail(s) |
[email protected]
|
| Organization name |
Karolinska Institutet
|
| Department |
Clinical neuroscience
|
| Lab |
Svensson-Brundin
|
| Street address |
Solnavägen 30
|
| City |
Stockholm |
| State/province |
Stockholm |
| ZIP/Postal code |
17177 |
| Country |
Sweden |
| |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA515305 |
| SRA |
SRP179652 |
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