|
| Status |
Public on Aug 10, 2020 |
| Title |
Gut microbiome communication with the bone marrow regulates intestinal inflammation and susceptibility to amebiasis. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We discovered that colonization of the gut with the human bile acid 7'-dehydroxylating bacteria Clostridia scindens provided immunity to the parasite E. histolytica in a murine model, increased granulocyte monocyte progenitors, and that adoptive marrow transplant from C. scindens colonized mice into naive mice could recapitualte this protection.
|
| |
|
| Overall design |
RNA-seq in granulocyte monocyte progenitors
|
| |
|
| Contributor(s) |
Burgess SL, Turner SD, Petri WA |
| Citation(s) |
32369444 |
| |
| Submission date |
Oct 18, 2018 |
| Last update date |
Aug 10, 2020 |
| Contact name |
Stephen Turner |
| Organization name |
Signature Science, LLC
|
| Street address |
1670 Discovery Drive
|
| City |
Charlottesville |
| State/province |
VA |
| ZIP/Postal code |
22911 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (12)
|
| GSM3438383 |
sample S04 CS status C. scindens (ATCC(R) 35704) |
| GSM3438384 |
sample S05 CS status C. scindens (ATCC(R) 35704) |
| GSM3438385 |
sample S06 CS status C. scindens (ATCC(R) 35704) |
| GSM3438386 |
sample S07 CS status none |
| GSM3438387 |
sample S08 CS status none |
| GSM3438388 |
sample S09 CS status none |
| GSM3438389 |
sample S10 CS status C. scindens (ATCC(R) 35704) |
| GSM3438390 |
sample S11 CS status C. scindens (ATCC(R) 35704) |
| GSM3438391 |
sample S12 CS status C. scindens (ATCC(R) 35704) |
|
| Relations |
| BioProject |
PRJNA497478 |
| SRA |
SRP166132 |
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