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| Status |
Public on Oct 30, 2018 |
| Title |
Expression data from prostate cancer LNCaP-AdtHs cells in response to androgen, ADT, normoxia, or hypoxia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Androgen and hypoxia are two cancer hallmark pathways; both exert biological effects primarily via the regulation of gene expression
We used gene expression array to determine the global gene expression changes due to androgen, castration (androgen-free) in normoxia and hypoxia conditions. Microarray assays were performed in the OHSU Gene Profiling Shared Resource
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| Overall design |
Androgen responsive human prostate cancer LNCaP-AdtHs cells were cultured in four conditions: with 5% charcoal-stripped FBS (CSS) (ADT), 5% CSS + 1nM synthetic androgen R1881 (R1881) in 20% oxygen (normoxia) or in 1% oxygen (hypoxia).
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| Contributor(s) |
Qian DZ |
| Citation(s) |
30478344 |
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| Submission date |
Sep 23, 2018 |
| Last update date |
Dec 06, 2018 |
| Contact name |
David Qian |
| E-mail(s) |
[email protected]
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| Phone |
5033125912
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| Organization name |
Oregon Health & Science University
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| Street address |
3303 SW Bond Ave, CH14R
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| City |
Portland |
| ZIP/Postal code |
97239 |
| Country |
USA |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (12)
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| GSM3398521 |
Cells with R1881, biological rep 1 |
| GSM3398522 |
Cells with R1881, biological rep 2 |
| GSM3398523 |
Cells with R1881, biological rep 3 |
| GSM3398524 |
Cells with R1881 in hypoxia, biological rep 1 |
| GSM3398525 |
Cells with R1881 in hypoxia, biological rep 2 |
| GSM3398526 |
Cells with R1881 in hypoxia, biological rep 3 |
| GSM3398527 |
Cells with ADT in hypoxia, biological rep 1 |
| GSM3398528 |
Cells with ADT in hypoxia, biological rep 2 |
| GSM3398529 |
Cells with ADT in hypoxia, biological rep 3 |
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| Relations |
| BioProject |
PRJNA492799 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE120343_RAW.tar |
25.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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