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| Status |
Public on Apr 11, 2019 |
| Title |
Gene expression changes upon depletion of H3K36 methylation by mutating met-1 and RNAi depleting mes-4 in worm L1 larvae |
| Organism |
Caenorhabditis elegans |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We compared wild type N2 fed L4440 control RNAi to met-1 mutants fed mes-4 RNAi food. Genes tend to be upregulated rather than downregulated in these mutants. Comparison to available ChIPseq datasets indicates that the upregulated genes are heterochromatic and are not enriched for H3K36 methylation, indicating that H3K36me loss derepresses heterochromatin indirectly.
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| |
|
| Overall design |
Comparison of 2 independent biological replicas
|
| |
|
| Contributor(s) |
Cabianca DS, Gaidatzis D |
| Citation(s) |
31118512 |
| |
| Submission date |
Jun 19, 2018 |
| Last update date |
May 31, 2019 |
| Contact name |
Dimos Gaidatzis |
| E-mail(s) |
[email protected]
|
| Organization name |
Friedrich Miescher Institute
|
| Street address |
Maulbeerstrasse 66
|
| City |
Basel |
| ZIP/Postal code |
4058 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL18245 |
Illumina HiSeq 2500 (Caenorhabditis elegans) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE116037 |
Active chromatin marks, H3K36me and MRG-1, drive spatial sequestration of heterochromatin |
|
| Relations |
| BioProject |
PRJNA476763 |
| SRA |
SRP150845 |
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