|
| Status |
Public on Jan 19, 2018 |
| Title |
Integrative genomic analysis in HCC samples [MYH] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We integrated the copy number data with gene expression data from the same HCC samples, and identified fifteen putative driver genes with recurrently genomic aberrations and their associated modules in HCC. We further confirmed empirically that three putative driver genes (MYH10, CEP104 and RRS1) play significant roles in tumor initiation and progression of HCC. Notably, we demonstrated that RRS1 regulates the MDM2-P53 pathway and promotes tumor progression by retaining RPL11 in the nucleolus in HCC. Altogether, these data provide insights into novel cancer driver genes and suggested molecular targets for treatment for HCC.
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| |
|
| Overall design |
Total RNA obtained from the human HepG2 cells with MYH10 shRNAs or HepG2 with control shRNA. Three biological replicates each.
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| |
|
| Contributor(s) |
Li P, Han Y, Cao P, Xia X, Chen X, Zhou G |
| Citation(s) |
34433556, 34738311 |
| |
| Submission date |
Jan 18, 2018 |
| Last update date |
Jan 07, 2022 |
| Contact name |
Gangqiao Zhou |
| E-mail(s) |
[email protected]
|
| Organization name |
Beijing Institute of Radiation Medicine
|
| Street address |
No. 27, Taiping Road, Haidian District
|
| City |
Beijing |
| ZIP/Postal code |
102206 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (6)
|
| GSM2940365 |
HepG2 cells with control shRNA, biological replicate 1 [shCt-1] |
| GSM2940366 |
HepG2 cells with control shRNA, biological replicate 2 [shCt-2] |
| GSM2940367 |
HepG2 cells with control shRNA, biological replicate 3 [shCt-3] |
| GSM2940368 |
HepG2 cells with MYH10 shRNAs, biological replicate 1 [shMYH10-1] |
| GSM2940369 |
HepG2 cells with MYH10 shRNAs, biological replicate 2 [shMYH10-2] |
| GSM2940370 |
HepG2 cells with MYH10 shRNAs, biological replicate 3 [shMYH10-3] |
|
| This SubSeries is part of SuperSeries: |
| GSE109361 |
Integrative genomic analysis in HCC samples |
|
| Relations |
| BioProject |
PRJNA430684 |
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