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| Status |
Public on Mar 11, 2008 |
| Title |
Transcriptional profiling and comparative genomic analysis of an invasive and non-invasive strain of Candida albicans |
| Organism |
Candida albicans |
| Experiment type |
Genome variation profiling by array
|
| Summary |
Invasion of host tissue by the human fungal pathogen, Candida albicans is an important step during many forms of candidosis. However, not all C. albicans strains possess the same invasive and virulence properties. It is known for example that the two clinical isolates SC5314 and ATCC10231 differ in their ability to invade into host tissue and to cause infections. Strain SC5314 is invasive whereas strain ATCC10231 is non-invasive and strongly attenuated in virulence as compared to SC5314. In this study we compare the in vitro transcriptional profiles and the genotypic profiles of these two widely used laboratory strains in order to determine the principal biological and genetic properties which may govern the different potential for invasiveness and virulence.
Keywords: transcriptional profiling, comparative genomic hybridisation, invasive vs. non-invasive C. albicans strain
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| Overall design |
Genomic DNA from C. albicans strains SC5314 and ATCC10231 hybridisations were done in duplicate including one dye swap.
Total RNA from C. albicans strains SC5314 and ATCC10231 strains were compared in triplicate including one biological replicate and one dye swap.
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| Contributor(s) |
Thewes S, Hube B, Moran GP, Sullivan DJ |
| Citation(s) |
17367383, 18950481 |
| |
| Submission date |
Mar 03, 2008 |
| Last update date |
Mar 19, 2012 |
| Contact name |
Bernhard Hube |
| E-mail(s) |
[email protected]
|
| Organization name |
Hans Knoell Institute
|
| Street address |
Beutenbergstr. 11a
|
| City |
Jena |
| ZIP/Postal code |
07745 |
| Country |
Germany |
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| Platforms (1) |
| GPL6453 |
Eurogentec Candida albicans 6k microarray (condensed) |
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| Samples (2) |
| GSM269806 |
Transcriptional profiling of invasive and non-invasive C. albicans strains |
| GSM269807 |
Comparative genome hybridisation of an invasive and non-invasive C. albicans strain |
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| Relations |
| BioProject |
PRJNA107679 |
