|
| Status |
Public on Dec 19, 2008 |
| Title |
Gene expression profile of H187-63AR, an ABT-737 resistant derivative of H187 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
ABT-737 is a highly potent small molecule inhibitor of Bcl-2 which has demonstrated efficacy in preclinical studies. To identify factors which mediate ABT-737 sensitivity we created an ABT-737-resistant cell line derivative. This cell lines maintained its ABT-737 resistance in vitro and in vivo. We isolated RNA from H187-63AR xenografts and compared their global gene expression to H187 xenografts.
Keywords: Tumor comparison
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| |
|
| Overall design |
Gene expression profiles of H187 and H187-63AR derivative tumors were compared. Two tumors from each group were compared.
The raw data file (21208_Hann_nonorm_nobkgd_GEOarchive_Matrix.txt) contains the following:
1688628038_B - H187 Control 1 (57)
1688628038_C - H187 Control 2 (58)
1688628038_E - H187-63AR 1 (513)
1688628038_H - H187-63AR 1 (565)
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| |
|
| Contributor(s) |
Hann CL, Rudin CM |
| Citation(s) |
18381439 |
| |
| Submission date |
Dec 21, 2007 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Christine Hann |
| Organization name |
Johns Hopkins University School of Medicine
|
| Department |
Oncology
|
| Lab |
Rudin
|
| Street address |
1550 Orleans St., CRB2, Rm 562
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21231 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6104 |
Illumina humanRef-8 v2.0 expression beadchip |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA108185 |
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