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    CRISP3 cysteine rich secretory protein 3 [ Homo sapiens (human) ]

    Gene ID: 10321, updated on 27-Nov-2024

    Summary

    Official Symbol
    CRISP3provided by HGNC
    Official Full Name
    cysteine rich secretory protein 3provided by HGNC
    Primary source
    HGNC:HGNC:16904
    See related
    Ensembl:ENSG00000096006 MIM:618062; AllianceGenome:HGNC:16904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3
    Summary
    This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
    Expression
    Biased expression in salivary gland (RPKM 504.8), bone marrow (RPKM 138.4) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CRISP3 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49727376..49744388, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49569352..49586363, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49695089..49712101, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Rh associated glycoprotein Neighboring gene GATA motif-containing MPRA enhancer 217 Neighboring gene Sharpr-MPRA regulatory region 4614 Neighboring gene MPRA-validated peak5838 silencer Neighboring gene cysteine rich secretory protein 2 Neighboring gene MPRA-validated peak5839 silencer Neighboring gene phosphoglycerate kinase 2 Neighboring gene uncharacterized LOC101927020 Neighboring gene uncharacterized LOC101927048

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126588

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in specific granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cysteine-rich secretory protein 3
    Names
    specific granule protein (28 kDa)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190986.3NP_001177915.1  cysteine-rich secretory protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001177915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2 which is longer than isoform 1.
      Source sequence(s)
      AL121950, BC069580, DB206136, X95240
      Consensus CDS
      CCDS55019.1
      UniProtKB/Swiss-Prot
      A8K9S1, B2R8I8, P54108, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
      Related
      ENSP00000389026.2, ENST00000433368.6
      Conserved Domains (2) summary
      cd05383
      Location:60197
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:214268
      Crisp; Crisp
    2. NM_001368123.1NP_001355052.1  cysteine-rich secretory protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AL121950, AL121974, DB204588
      Consensus CDS
      CCDS93932.1
      UniProtKB/Swiss-Prot
      A8K9S1, B2R8I8, P54108, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
      UniProtKB/TrEMBL
      J3KPA1
      Related
      ENSP00000360201.4, ENST00000371159.8
    3. NM_006061.4NP_006052.2  cysteine-rich secretory protein 3 isoform 1

      See identical proteins and their annotated locations for NP_006052.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL121950, DB210604, X95240
      Consensus CDS
      CCDS4929.2
      UniProtKB/Swiss-Prot
      A8K9S1, B2R8I8, P54108, Q15512, Q3MJ82, Q53FA9, Q5JW83, Q9H108
      Related
      ENSP00000263045.4, ENST00000263045.9
      Conserved Domains (2) summary
      cd05383
      Location:50187
      SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
      pfam08562
      Location:204258
      Crisp; Crisp

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      49727376..49744388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      49569352..49586363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)