NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|300244560|ref|NP_006052|]
View 

cysteine-rich secretory protein 3 isoform 1 [Homo sapiens]

Protein Classification

CRISP family CAP domain-containing protein( domain architecture ID 10143563)

CRISP (cysteine-rich secretory protein) family CAP (CSP/antigen 5/PR1) domain-containing protein similar to Varanus acanthurus cysteine-rich venom proteins that block ryanodine receptors, and potassium channels

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 50-187 6.64e-83

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


:

Pssm-ID: 349402  Cd Length: 139  Bit Score: 244.19  E-value: 6.64e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  50 QVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRM-TSLKCGENLYMSSASSSWSQAIQS 128
Cdd:cd05383    1 KVQQEIVDLHNALRRSVNPPASNMLKMSWNPEAAENAQRWANRCNFTHSPPNGRTiPGIRCGENIFMSSYPASWSEVIQA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 300244560 129 WFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPA 187
Cdd:cd05383   81 WYDEYKDFKYGVGAKPPGSVTGHYTQVVWYSSYLVGCAVAYCPSQGSLKYFYVCQYCPA 139
Crisp pfam08562
Crisp; This domain is found on Crisp proteins which contain pfam00188 and has been termed the ...
 204-258 6.38e-26

Crisp; This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.


:

Pssm-ID: 462519  Cd Length: 55  Bit Score: 96.17  E-value: 6.38e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 300244560  204 CASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY 258
Cdd:pfam08562   1 CGDCPNNCEDKLCTNPCPYVDLYSNCDELKKTFGCEHPLVKKNCKASCKCTTEIK 55
 
Name Accession Description Interval E-value
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 50-187 6.64e-83

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 244.19  E-value: 6.64e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  50 QVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRM-TSLKCGENLYMSSASSSWSQAIQS 128
Cdd:cd05383    1 KVQQEIVDLHNALRRSVNPPASNMLKMSWNPEAAENAQRWANRCNFTHSPPNGRTiPGIRCGENIFMSSYPASWSEVIQA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 300244560 129 WFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPA 187
Cdd:cd05383   81 WYDEYKDFKYGVGAKPPGSVTGHYTQVVWYSSYLVGCAVAYCPSQGSLKYFYVCQYCPA 139
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 50-186 9.60e-47

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 152.54  E-value: 9.60e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560    50 QVQREIVNKHNELRRAVS------PPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDrmtslKCGENLYMSSASSSWS 123
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAggflaaPAASNMLKLTWDCELASSAQNWANQCPFGHSTPRP-----GYGENLAWWSSSTALP 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300244560   124 Q-----AIQSWFDEYNDFDFGVG-PKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCP 186
Cdd:smart00198  76 DtyasaAVQLWYDEFQDYGYSSNtCKDTNGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTVVVCNYDP 144
Crisp pfam08562
Crisp; This domain is found on Crisp proteins which contain pfam00188 and has been termed the ...
 204-258 6.38e-26

Crisp; This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.


Pssm-ID: 462519  Cd Length: 55  Bit Score: 96.17  E-value: 6.38e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 300244560  204 CASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY 258
Cdd:pfam08562   1 CGDCPNNCEDKLCTNPCPYVDLYSNCDELKKTFGCEHPLVKKNCKASCKCTTEIK 55
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 56-184 5.97e-14

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 66.46  E-value: 5.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560   56 VNKHNELRRAvsppaRNMLKMEWNKEAAANAQKWANQCNYRHS-NPKDrmtslKCGENLYM----------SSASSSWSQ 124
Cdd:pfam00188   1 LDLHNEYRAA-----AGLPPLSWDNELAAAAQDHAKYCADNGShNHRS-----PYGGNIYArvvaagyalgDAGPDSAED 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  125 AIQSWFDEYNDFDfgvgpktpnavVGHYTQVVWYSSYLVGCGNAYCPNQKvlKYYYVCQY 184
Cdd:pfam00188  71 AVDGWYDSPGTYN-----------CGHRTNLLWPKSTKVGCAVAKCGDGG--TYYFVCNY 117
 
Name Accession Description Interval E-value
CAP_CRISP cd05383
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 50-187 6.64e-83

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory proteins; Cysteine-rich secretory proteins (CRISPs) are two-domain proteins with an evolutionary diverse and structurally conserved N-terminal CAP domain and a C-terminal cysteine-rich domain, which is comprised of a hinge and an ICR (ion channel regulator) region. CRISPs are involved in response to pathogens, fertilization, and sperm maturation. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. CRISP-1 has been shown to mediate gamete fusion by binding to the egg surface. Other members of the CRISP family secreted in the testis (CRISP2), epididymis (CRISP3-4), or during ejaculation (CRISP3), are also involved in sperm-egg interaction, supporting the existence of a functional redundancy and cooperation between homolog proteins ensuring the success of fertilization. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1) and allergen 5 from vespid venom, among others.


Pssm-ID: 349402  Cd Length: 139  Bit Score: 244.19  E-value: 6.64e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  50 QVQREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRM-TSLKCGENLYMSSASSSWSQAIQS 128
Cdd:cd05383    1 KVQQEIVDLHNALRRSVNPPASNMLKMSWNPEAAENAQRWANRCNFTHSPPNGRTiPGIRCGENIFMSSYPASWSEVIQA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 300244560 129 WFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCPA 187
Cdd:cd05383   81 WYDEYKDFKYGVGAKPPGSVTGHYTQVVWYSSYLVGCAVAYCPSQGSLKYFYVCQYCPA 139
SCP smart00198
SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma ...
 50-186 9.60e-47

SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains; Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.


Pssm-ID: 214553 [Multi-domain]  Cd Length: 144  Bit Score: 152.54  E-value: 9.60e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560    50 QVQREIVNKHNELRRAVS------PPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDrmtslKCGENLYMSSASSSWS 123
Cdd:smart00198   1 AQQQEILDAHNKLRSQVAggflaaPAASNMLKLTWDCELASSAQNWANQCPFGHSTPRP-----GYGENLAWWSSSTALP 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300244560   124 Q-----AIQSWFDEYNDFDFGVG-PKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQYCP 186
Cdd:smart00198  76 DtyasaAVQLWYDEFQDYGYSSNtCKDTNGKIGHYTQVVWAKTYKVGCGVANCPDGTKKKTVVVCNYDP 144
CAP cd00168
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 54-185 4.31e-44

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain, also called SCP (sperm-coating glycoprotein), is found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in cell wall loosening. This family also includes CRISPs (cysteine-rich secretory proteins), which combine the CAP/SCP domain with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. Roles for CRISP, in response to pathogens, fertilization, and sperm maturation have been proposed. One member, Tex31 from the venom duct of Conus textile, has been shown to possess proteolytic activity sensitive to serine protease inhibitors. The human GAPR-1 protein has been reported to dimerize, and such a dimer may form an active site containing a catalytic triad. CAP/SCP has also been proposed to be a Ca++ chelating serine protease. The Ca++-chelating function would fit with various signaling processes that members of this family, such as the CRISPs, are involved in, and is supported by sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine, a toxic peptide secreted by the beaded lizard, blocks Ca++ transporting ryanodine receptors. Little is known about the biological roles of the bacterial and archaeal CAP/SCP domains.


Pssm-ID: 349397  Cd Length: 128  Bit Score: 145.45  E-value: 4.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  54 EIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMtslKCGENLYMSSASSSWSQAIQSWFDEY 133
Cdd:cd00168    3 EILDLHNSYRSSVSPPASNMPLMAWDQELADVAIGYAKDCIFSHSSPTSRQ---LAGENIAASSYDMDGVAALQAWHNEI 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 300244560 134 NDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQkvlKYYYVCQYC 185
Cdd:cd00168   80 KNYNFGTAQPGFNSGTGHYTQMVWEKTTKLGCGVADCSDN---SKFVVCNYI 128
CAP_euk cd05380
Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 ...
 52-184 4.15e-39

Eukaryotic CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins; The CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain is found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), and allergen 5 from vespid venom.


Pssm-ID: 349399  Cd Length: 144  Bit Score: 132.96  E-value: 4.15e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  52 QREIVNKHNELRRAVS-------PPARNMLKMEWNKEAAANAQKWANQCNYRHSNPKDRMTSlkcGENLYMSSASSSWS- 123
Cdd:cd05380    1 RQEILDAHNELRSKVAkgklkglPPAANMPKLKWDCELAKLAQNWAKTCVFAHSPCRNTGGV---GQNLASVSSSGKDLk 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300244560 124 ----QAIQSWFDEYNDFDFGVGP-KTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYYYVCQY 184
Cdd:cd05380   78 elieDAVNAWFDELKDYGFGSNPnNNFNSGIGHFTQMVWAKTTKVGCAVARCPKGGGNKTYVVCNY 143
CAP_PI16_HrTT-1 cd05559
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 52-184 9.16e-31

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein; Human peptidase inhibitor 16 (PI16) is also called cysteine-rich secretory protein 9 (CRISP-9) or PSP94-binding protein. Mouse PI16 is also called cysteine-rich protease inhibitor. PI16 is predominantly expressed by cardiac fibroblasts and is exposed to the interstitium via a glycophosphatidylinositol (-GPI) membrane anchor. It suppresses the activation of the chemokine chemerin in the myocardium, which may be a part of the cardiac stress response. At high endothelial shear stress, PI16 is an inflammation-regulated inhibitor of matrix metalloproteinase 2 (MMP2). Also included in this subfamily is the HrTT-1 protein, a tail-tip epidermis marker in ascidians. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349405  Cd Length: 134  Bit Score: 111.36  E-value: 9.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  52 QREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHsNPKDRMTslkcGENLY-MSSASSSWSQAIQSWF 130
Cdd:cd05559    1 KKLLVDLHNQYRSQVSPSAANMLKMTWDTELEALAKAYARKCIWEH-NPDRGRV----GENLFaSTGKPLDVELAVEDWH 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 300244560 131 DEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLK----YYYVCQY 184
Cdd:cd05559   76 NEKEYYNFETKTCAPGKMCGHYTQVVWANTEKIGCGSYFCETLEGVEwenaTLLVCNY 133
CAP_GLIPR1-like cd05385
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 53-188 1.93e-29

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of glioma pathogenesis-related protein 1 and similar proteins; Glioma pathogenesis-related protein 1 (GLIPR1) is also called related to testes-specific, vespid, and pathogenesis protein 1 (RTVP-1). The GLIPR1 gene has been identified as a p53 target gene and was shown to be methylated and down-regulated in prostate cancer. It is a novel broad-spectrum tumor suppressor whose proapoptotic properties are exerted in part through ROS-JNK signaling. GLIPR1 is composed of a signal peptide that directs its secretion, a CAP domain, and a transmembrane domain. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349404  Cd Length: 148  Bit Score: 108.26  E-value: 1.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  53 REIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHsNPKDRmTSLKC-------GENLYMSSASSSWSQ- 124
Cdd:cd05385    4 DECVRIHNELRSKVSPPAANMRYMSWDKALAKTARAWARKCKFSH-NICLK-EPGKChpnfttlGENIWLGSIFSFSVEs 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300244560 125 AIQSWFDEYNDFDFGVGpkTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKVLKYY-----YVCQYCPAG 188
Cdd:cd05385   82 AITSWYNEVKDYNFKTN--SCSRVCGHYTQVVWADSYKVGCAVHVCPNGGGFFSGsssaiFVCNYGPAG 148
Crisp pfam08562
Crisp; This domain is found on Crisp proteins which contain pfam00188 and has been termed the ...
 204-258 6.38e-26

Crisp; This domain is found on Crisp proteins which contain pfam00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK.


Pssm-ID: 462519  Cd Length: 55  Bit Score: 96.17  E-value: 6.38e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 300244560  204 CASCPDNCDDGLCTNGCKYEDLYSNCKSLKLTLTCKHQLVRDSCKASCNCSNSIY 258
Cdd:pfam08562   1 CGDCPNNCEDKLCTNPCPYVDLYSNCDELKKTFGCEHPLVKKNCKASCKCTTEIK 55
CAP_GAPR1-like cd05382
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 52-190 1.59e-24

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins; Golgi-associated plant pathogenesis related protein 1 (GAPR1), also called Golgi-associated PR-1 protein or glioma pathogenesis-related protein 2 (GLIPR-2), forms amyloid-like fibrils in the presence of liposomes containing acidic phospholipids. It has been identified in mice as an up-regulated protein in kidney fibrosis, and is involved in epithelial to mesenchymal transition and in generating a pool of myofibroblasts contributing to fibrosis. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349401  Cd Length: 132  Bit Score: 94.97  E-value: 1.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  52 QREIVNKHNELRRA-VSPParnmlkMEWNKEAAANAQKWANQCNYR----HSNPKdrmtslKCGENLYMSSASSSWS--- 123
Cdd:cd05382    3 QKECLKAHNEYRALhGAPP------LKLDKELSKEAQKWAEKLASSgtlqHSSPS------SYGENLAYFSGSGYDLtge 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300244560 124 QAIQSWFDEYNDFDFGVGPKTPNAvvGHYTQVVWYSSYLVGCGNAycpNQKVLKYYYVCQYCPAGNW 190
Cdd:cd05382   71 EAVDSWYNEIKNYNFNKPGFQSGT--GHFTQVVWKSSTELGVGVA---KSKDGCVYVVARYSPAGNV 132
CAP_PR-1 cd05381
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 52-193 4.55e-22

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogenesis-related protein 1 (PR-1) family proteins; Members of pathogenesis-related protein 1 (PR-1) family are among the most abundantly produced proteins in plants on pathogen attack. They are considered hallmarks of hypersensitive response/defense pathways and may act as anti-fungal agents or be involved in cell wall loosening.


Pssm-ID: 349400  Cd Length: 136  Bit Score: 88.46  E-value: 4.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  52 QREIVNKHNELRRAVSPPArnmlkMEWNKEAAANAQKWANQ----CNYRHSNPKdrmtslkCGENLYMSSASSSW-SQAI 126
Cdd:cd05381    1 PQDFLDAHNQARAAVGVPP-----LVWDDTLAAYAQKYANQrrgdCSLVHSNGP-------YGENLFWGSGDNWSpADAV 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300244560 127 QSWFDEYNDFDFGVGPKTPNAVVGHYTQVVWYSSYLVGCGNAYCPNQKvlKYYYVCQYCPAGNWANR 193
Cdd:cd05381   69 KSWVDEKPYYDYASNTCVGGKMCGHYTQVVWRNSTRLGCARVVCDNNG--GTFVICNYDPPGNYIGE 133
CAP_PRY1-like cd05384
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 50-192 1.53e-21

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; PRY1, also called pathogenesis-related protein 1, is a yeast protein that is up-regulated in core ESCRT mutants. It is a secreted protein required for efficient export of lipids such as acetylated sterols, and acts in detoxification of hydrophobic compounds. This PRY1-like group also contains fruiting body proteins SC7/14 from Schizophyllum commune. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349403  Cd Length: 129  Bit Score: 87.00  E-value: 1.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  50 QVQREIVNKHNELRRAVSPPArnmlkMEWNKEAAANAQKWANQC----NYRHSNpkdrmtsLKCGENL---YMSSASssw 122
Cdd:cd05384    1 SFASSILDAHNKKRALHGTQP-----LTWNDTLAEYAQDYADSYdcsgNLVHSG-------GPYGENLalgYSSGAA--- 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560 123 sqAIQSWFDEYNDFDFGVGPKTpnAVVGHYTQVVWYSSYLVGCGNAYCPNQKvlKYYYVCQYCPAGNWAN 192
Cdd:cd05384   66 --AVDAWYDEISDYDYSNPGFS--ESTGHFTQLVWKSTTQVGCAYKDCGGAW--GLYIVCEYDPAGNVIG 129
CAP_CRISPLD2 cd18816
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 52-184 1.89e-18

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 2; Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) is also called cysteine-rich secretory protein 11 (CRSIP-11), LCCL domain-containing cysteine-rich secretory protein 2 (LCRISP2), or CAP and LCCL domain containing protein 2 (CAPLD2). It plays a role in the etiology of NSCLP (non-syndromic cleft lip with or without cleft palate). It is required for neural crest cell migration and cell viability during craniofacial development. The CRISPLD2 gene has been identified a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349410  Cd Length: 146  Bit Score: 79.26  E-value: 1.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  52 QREIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSnPKDRMTSLkcGENLYMS-SASSSWSQAIQSWF 130
Cdd:cd18816    1 KEEILQLHNKLRGQVYPSASNMEYMTWDDELERSAEAWAQQCIWEHG-PTSLLPSI--GQNLAVHwGRYRSPAFHVQSWY 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300244560 131 DEYNDFDF----GVGPKTPNAVVG----HYTQVVWYSSYLVGCGNAYCPNQKVL------KYYYVCQY 184
Cdd:cd18816   78 DEVKDYTYpyphECNPWCPERCSGpmctHYTQIVWATTNKVGCAVNVCRRMNVWgeiwenAVYLVCNY 145
CAP_PI15-like cd18812
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 54-184 8.83e-18

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15 and similar proteins; This family is composed of peptidase inhibitor 15 (PI15), peptidase inhibitor R3HDML, cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1), and cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2). PI15 is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. R3HDML is a putative serine protease inhibitor, whose gene may be associated with clinical dimensions of schizophrenia. CRISPLD1 may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. plays a role in the etiology of NSCLP and is required for neural crest cell migration and cell viability during craniofacial development. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349406  Cd Length: 146  Bit Score: 77.64  E-value: 8.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  54 EIVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSnPKDRMTSLkcGENLYMSS-ASSSWSQAIQSWFDE 132
Cdd:cd18812    3 AILDYHNKLRGQVYPPAANMEYMVWDKELARSAEAWATQCIWEHG-PSSLLRSI--GQNLSAHWgRYRSPVFLVKSWYDE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300244560 133 YNDFDF----GVGPKTPNAVVG----HYTQVVWYSSYLVGCGNAYCPNQKVL------KYYYVCQY 184
Cdd:cd18812   80 VKDYLFpyprDCNPHCPWRCSGpmctHYTQMVWATSNRIGCAIHTCSNMNVWgnvwhrAVYLVCNY 145
CAP_CRISPLD1 cd18813
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 55-184 3.05e-17

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of cysteine-rich secretory protein LCCL domain-containing 1; Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) is also called cysteine-rich secretory protein 10 (CRISP-10), CocoaCrisp, LCCL domain-containing cysteine-rich secretory protein 1 (LCRISP1), or CAP and LCCL domain containing protein 1 (CAPLD1). CRISPLD1 is clearly distinct from CRISPs because they do not contain the 10 absolutely conserved cysteines or the ICR (ion channel regulator) domain of the CRISPs. It may play a role in NSCLP (nonsyndromic cleft lip with or without cleft palate) through the interaction with CRISPLD2 and folate pathway genes. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349407  Cd Length: 146  Bit Score: 76.20  E-value: 3.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  55 IVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSnPKDRMTSLkcGENLYMSSASSSWSQ-AIQSWFDEY 133
Cdd:cd18813    4 ILDLHNKLRGQVYPPASNMEYMTWDVELERSAEAWAETCLWEHG-PAHLLPSI--GQNLGAHWGRYRPPTfHVQAWYDEV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300244560 134 NDFDF----GVGPKTP----NAVVGHYTQVVWYSSYLVGCGNAYCPNQKVL------KYYYVCQY 184
Cdd:cd18813   81 RDFSYpypqECNPYCPfrcsGPVCTHYTQVVWATSNRIGCAINLCHNMNVWgqiwpkAIYLVCNY 145
CAP_PI15 cd18814
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 55-184 3.43e-16

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 15; Peptidase inhibitor 15 (PI15) is also called 25 kDa trypsin inhibitor (p25TI), cysteine-rich secretory protein 8 (CRISP-8), or SugarCrisp. It is a serine protease inhibitor which displays weak inhibitory activity against trypsin and may play a role in facial patterning during embryonic development. The PI15 gene is a candidate gene for abdominal aortic internal elastic lamina ruptures in the rat. PI15 may also participate in the regulation of drug resistance in ovarian cancer and serve as a potential target in targeted therapies. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349408  Cd Length: 146  Bit Score: 73.50  E-value: 3.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  55 IVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSnPKDRMTSLkcGENLYMSS-ASSSWSQAIQSWFDEY 133
Cdd:cd18814    4 ILDYHNQVRGKVFPPAANMEYMVWDENLAKSAEAWAATCIWDHG-PSYLLRFL--GQNLSVRTgRYRSILQLVKPWYDEV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300244560 134 NDFDF----GVGPKTPNAVVG----HYTQVVWYSSYLVGCGNAYCPNQKVL------KYYYVCQY 184
Cdd:cd18814   81 KDYAFpypqDCNPRCPLRCYGpmctHYTQMVWATSNRIGCAIHTCHNMNVWgsvwrrAVYLVCNY 145
CAP_R3HDML cd18815
CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain ...
 55-184 5.24e-16

CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor R3HDML; Peptidase inhibitor R3HDML, also called cysteine-rich secretory protein R3HDML, is a putative serine protease inhibitor. The R3HDML gene may be associated with clinical dimensions of schizophrenia. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others.


Pssm-ID: 349409  Cd Length: 146  Bit Score: 72.62  E-value: 5.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  55 IVNKHNELRRAVSPPARNMLKMEWNKEAAANAQKWANQCNYRHSnPKDRMTSLkcGENLYMSS-ASSSWSQAIQSWFDEY 133
Cdd:cd18815    4 LLDYHNRVRSQVFPPAANMEYMVWDERLAKSAEAWAAQCVWEHG-PPQLMRYI--GQNLSIHSgRYRSIVDLVKSWYDER 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300244560 134 NDFDF----GVGPKTPN----AVVGHYTQVVWYSSYLVGCGNAYCPNQKVL------KYYYVCQY 184
Cdd:cd18815   81 QHYSFphprECNPRCPSkcsgAVCSHYTQMVWASSNRIGCAVHTCSNINVWgstwrrATYLVCNY 145
CAP pfam00188
Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory ...
 56-184 5.97e-14

Cysteine-rich secretory protein family; This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organizms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilization. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.


Pssm-ID: 395136  Cd Length: 117  Bit Score: 66.46  E-value: 5.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560   56 VNKHNELRRAvsppaRNMLKMEWNKEAAANAQKWANQCNYRHS-NPKDrmtslKCGENLYM----------SSASSSWSQ 124
Cdd:pfam00188   1 LDLHNEYRAA-----AGLPPLSWDNELAAAAQDHAKYCADNGShNHRS-----PYGGNIYArvvaagyalgDAGPDSAED 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 300244560  125 AIQSWFDEYNDFDfgvgpktpnavVGHYTQVVWYSSYLVGCGNAYCPNQKvlKYYYVCQY 184
Cdd:pfam00188  71 AVDGWYDSPGTYN-----------CGHRTNLLWPKSTKVGCAVAKCGDGG--TYYFVCNY 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH