| DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis. | DET1-mediated COP1 regulation avoids HY5 activity over second-site gene targets to tune plant photomorphogenesis.
Cañibano E, Bourbousse C, García-León M, Garnelo Gómez B, Wolff L, García-Baudino C, Lozano-Durán R, Barneche F, Rubio V, Fonseca S. | 01/8/2022 |
| DET1 regulates HY5 through COP1: A new paradigm in the regulation of HY5. | DET1 regulates HY5 through COP1: A new paradigm in the regulation of HY5.
Das S, Garhwal V, Gangappa SN. | 01/8/2022 |
| Mutation of CONSTITUTIVELY PHOTOMORPOGENIC1 (COP1), DE-ETIOLATED1, and CYTOKININ INSENSITIVE4/COP10 renders plants insensitive to cytokinin, and these factors are indispensable for the transcriptional response during cytokinin-induced de-etiolation, indicating that a functional light-signaling pathway is essential for this cytokinin response. | Ethylene-independent promotion of photomorphogenesis in the dark by cytokinin requires COP1 and the CDD complex.
Cortleven A, Ehret S, Schmülling T, Johansson H., Free PMC Article | 02/15/2020 |
| Authors show that a common signaling module integrates environmental signals, such as photoperiod and temperature, to regulate the growth-defense balance. Key light-signaling components De-Etiolated 1 (DET1) and Constitutive Photomorphogenic 1 (COP1) negatively regulate immunity and are essential for immune modulation by photoperiod and temperature. | DET1 and COP1 Modulate the Coordination of Growth and Immunity in Response to Key Seasonal Signals in Arabidopsis.
Gangappa SN, Kumar SV., Free PMC Article | 01/11/2020 |
| DET1-DDB1-Associated-1 (DDA1) protein interacts with SGF11 in vivo, linking the DET1 complex to light-dependent ubiquitin-mediated proteolytic degradation of the deubiquitination module. | DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis.
Nassrallah A, Rougée M, Bourbousse C, Drevensek S, Fonseca S, Iniesto E, Ait-Mohamed O, Deton-Cabanillas AF, Zabulon G, Ahmed I, Stroebel D, Masson V, Lombard B, Eeckhout D, Gevaert K, Loew D, Genovesio A, Breyton C, De Jaeger G, Bowler C, Rubio V, Barneche F., Free PMC Article | 01/12/2019 |
| These findings reveal a mechanistic framework in which DET1/COP1 and HY5 regulatory modules act independently to regulate growth through the environmental signal integrator PIF4. | DET1 and HY5 Control PIF4-Mediated Thermosensory Elongation Growth through Distinct Mechanisms.
Gangappa SN, Kumar SV., Free PMC Article | 11/25/2017 |
| Germination in det1 mutants is sensitive to ABA. Double mutant analysis indicates that det1 abscisic acid sensitive germination requires HY5 and ABI5. | Genetic interactions between DET1 and intermediate genes in Arabidopsis ABA signalling.
Fernando VC, Schroeder DF. | 07/16/2016 |
| DET1 is a strong repressor of flowering and has a pivotal role in maintaining photoperiod sensitivity in the regulation of flowering time. | Negative regulatory roles of DE-ETIOLATED1 in flowering time in Arabidopsis.
Kang MY, Yoo SC, Kwon HY, Lee BD, Cho JN, Noh YS, Paek NC., Free PMC Article | 03/5/2016 |
| PEX2 RING domain overexpression in det1 also partially suppresses the det1 phenotype. | Ectopic expression of the RING domain of the Arabidopsis peroxin2 protein partially suppresses the phenotype of the photomorphogenic mutant de-etiolated1.
Desai M, Kaur N, Hu J., Free PMC Article | 01/16/2016 |
| Genomic analysis also revealed that DET1 may modulate the expression of light-regulated genes to mediate photomorphogenesis partially through phytochrome-interacting factors. | Arabidopsis DE-ETIOLATED1 represses photomorphogenesis by positively regulating phytochrome-interacting factors in the dark.
Dong J, Tang D, Gao Z, Yu R, Li K, He H, Terzaghi W, Deng XW, Chen H., Free PMC Article | 11/14/2015 |
| Light and COP1 regulate level of overexpressed DET1 protein | Light and COP1 regulate level of overexpressed DET1 protein.
Ly V, Collister DT, Fonseca E, Liao TS, Schroeder DF. | 09/26/2015 |
| DET1 acts upstream of both HFR1 and PIF1 to predominantly repress seed germination. DET1 predominantly represses seed germination in the dark. | Arabidopsis DET1 degrades HFR1 but stabilizes PIF1 to precisely regulate seed germination.
Shi H, Wang X, Mo X, Tang C, Zhong S, Deng XW., Free PMC Article | 06/20/2015 |
| DDB1A and DDB1B contribute to DET1 regulation of adult plant growth. | Genetic interactions of Arabidopsis thaliana damaged DNA binding protein 1B (DDB1B) with DDB1A, DET1, and COP1.
Ganpudi AL, Schroeder DF., Free PMC Article | 09/28/2013 |
| The det1 acts epistatically to uvh6 with respect to de-etiolation, chlorophyll level, UV tolerance, and heat-induced growth inhibition. (DET1 protein) | Genetic interactions between Arabidopsis DET1 and UVH6 during development and abiotic stress response.
Kim E, Ly V, Hatherell A, Schroeder DF., Free PMC Article | 04/6/2013 |
| results reveal DET1 as a core transcriptional repression factor important for clock progression | Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock.
Lau OS, Huang X, Charron JB, Lee JH, Li G, Deng XW., Free PMC Article | 12/24/2011 |
| Altogether, these data suggest that DET1, CUL4 and DDB2 cooperate during the excision repair process. | The conserved factor DE-ETIOLATED 1 cooperates with CUL4-DDB1DDB2 to maintain genome integrity upon UV stress.
Castells E, Molinier J, Benvenuto G, Bourbousse C, Zabulon G, Zalc A, Cazzaniga S, Genschik P, Barneche F, Bowler C., Free PMC Article | 05/21/2011 |
| LHY ubiquitination by SINAT5 was inhibited by DET1. | Ubiquitination of LHY by SINAT5 regulates flowering time and is inhibited by DET1.
Park BS, Eo HJ, Jang IC, Kang HG, Song JT, Seo HS. | 08/16/2010 |
| Results show that SPA1 and DET1 act together to control photomorphogenesis throughout plant development. | SPA1 and DET1 act together to control photomorphogenesis throughout plant development.
Nixdorf M, Hoecker U. | 05/10/2010 |
| DDB1A-3HA overexpression affected phenotypes in a variety of DET1 backgrounds, reduced epitope-tagged DET1 levels, and, correlatively, in general dampened the rescue of det1 mutants by the DET1-DDB1A complex. | Effect of overexpression of Arabidopsis damaged DNA-binding protein 1A on de-etiolated 1.
Zhang Y, Schroeder DF. | 04/12/2010 |
| DDB1A-dependent phenotypes indicate a competition between DDB2- and DET1-containing complexes for available DDB1A, while, for DDB1A-independent phenotypes, DDB1B is able to fulfill this role. | DDB2, DDB1A and DET1 exhibit complex interactions during Arabidopsis development.
Al Khateeb WM, Schroeder DF., Free PMC Article | 01/21/2010 |
| Findings suggests a role for DET1 in a ubiquitination pathway and identify a substrate for DET1-regulated protein turn-over. | DET1 regulates the proteasomal degradation of LHY, a component of the Arabidopsis circadian clock.
Song HR, Carré IA. | 01/21/2010 |
| Arabidopsis cullin 4 is shown to assemble with DDB1, RBX1, DET1 and DDB2 in vitro and in planta. | CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana.
Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, Dubin MJ, Benvenuto G, Bowler C, Genschik P, Hellmann H. | 01/21/2010 |