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    Usp7 Ubiquitin-specific protease 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32169, updated on 17-Dec-2024

    Summary

    Official Symbol
    Usp7provided by FlyBase
    Official Full Name
    Ubiquitin-specific protease 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0030366
    Locus tag
    Dmel_CG1490
    See related
    AllianceGenome:FB:FBgn0030366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1490; Dmel\CG1490; Q9VYQ8; Usp-7; usp7; USP7
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in negative regulation of hippo signaling; positive regulation of heterochromatin formation; and positive regulation of smoothened signaling pathway. Located in chromosome; cytosol; and nucleus. Part of protein-containing complex. Is expressed in several structures, including adult head; central brain primordium; embryonic brain; and imaginal disc. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Usp7 in Genome Data Viewer
    Location:
    11A1-11A2; 1-38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12022837..12029032, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11916870..11923065, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene LSM12 homolog a Neighboring gene Transport and Golgi organization 4 Neighboring gene Cytochrome P450 311a1 Neighboring gene Cytochrome P450 318a1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in heterochromatin PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in polytene chromosome PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    Ubiquitin-specific protease 7
    Names
    CG1490-PB
    CG1490-PC
    Usp7-PB
    Usp7-PC
    ubiquitin-specific protease 7
    NP_001285149.1
    NP_572779.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12022837..12029032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132551.3 → NP_572779.2  Ubiquitin-specific protease 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572779.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJQ7, Q9VYQ8
      Related
      FBpp0073474
      Conserved Domains (1) summary
      COG5077
      Location:101 → 1119
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    2. NM_001298220.1 → NP_001285149.1  Ubiquitin-specific protease 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEX7
      Conserved Domains (5) summary
      COG5077
      Location:101 → 1115
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:239 → 549
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:100 → 229
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:647 → 879
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:893 → 1109
      USP7_C2; Ubiquitin-specific protease C-terminal
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