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    med15 mediator complex subunit 15 [ Danio rerio (zebrafish) ]

    Gene ID: 406346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    med15provided by ZNC
    Official Full Name
    mediator complex subunit 15provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2032
    See related
    Ensembl:ENSDARG00000014292 AllianceGenome:ZFIN:ZDB-GENE-040426-2032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pcqap; arc105; fi85b10; zgc:55839; wu:fd19g01; wu:fi19d01; wu:fi85b10
    Summary
    Predicted to enable transcription coregulator activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See med15 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (18929319..18946541, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (18892683..18909905, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488796 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene si:ch211-222n4.2 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog-like Neighboring gene serine/threonine-protein kinase pim-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Depletion of Med10 enhances Wnt and suppresses Nodal signaling during zebrafish embryogenesis. Lin X, et al. Dev Biol, 2007 Mar 15. PMID 17208216
    2. Molecular targets of TBBPA in zebrafish analysed through integration of genomic and proteomic approaches. De Wit M, et al. Chemosphere, 2008 Dec. PMID 18976794
    3. Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. Guna A, et al. J Neurodev Disord, 2015. PMID 26137170, Free PMC Article
    4. Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Campbell PD, et al. Mol Psychiatry, 2023 Sep. PMID 37794116, Free PMC Article
    5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 15
    Names
    PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
    activator-recruited cofactor 105 kDa component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213073.2 → NP_998238.2  mediator of RNA polymerase II transcription subunit 15

      Status: VALIDATED

      Source sequence(s)
      BC045472, CK030290, CU467622, CV488078, CV490828
      UniProtKB/TrEMBL
      A0A8M9PI73, F1QFA9
      Related
      ENSDARP00000003782.8, ENSDART00000021997.10
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 799
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      18929319..18946541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468800.2 → XP_021324475.1  mediator of RNA polymerase II transcription subunit 15 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PI73, A0A8M9PTS3
      Conserved Domains (1) summary
      pfam09606
      Location:17 → 763
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVN7.1 GenPept UniProtKB/Swiss-Prot:Q7ZVN7

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