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Conserved domains on  [gi|1207158831|ref|XP_021324475|]
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mediator of RNA polymerase II transcription subunit 15 isoform X1 [Danio rerio]

Protein Classification

mediator complex subunit 15 domain-containing protein; SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 12100911)

mediator complex subunit 15 (MED15) domain-containing protein may be involved in bridging enhancers and promoters and most of the proteins bearing these domains are transcriptional coactivators| SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; also contains a Med15 domain, a critical transducer of gene activation signals that control early metazoan development.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 17-763 2.42e-138

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 425.58  E-value: 2.42e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831  17 QKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKAQ-------------------GGP 77
Cdd:pfam09606   1 QSVVNKIEEALQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAqqqqpqggqgnggmgggqqGMP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831  78 DPINALQNLPGGvpgviGPRPPGAQMGGMGQMSMGPHAM--QGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQSIQFQT 155
Cdd:pfam09606  81 DPINALQNLAGQ-----GTRPQMMGPMGPGPGGPMGQQMggPGTASNLLASLGRPQMPMGGAGFPSQMSRVGRMQPGGQA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 156 FQPQQQQQATMQSQQPSAMFQQIRLQQLQQHHQNQQMQHQNQQQQQAqnqqqqnqlhqtRMQQQLQLQQLQQQQQQQQQL 235
Cdd:pfam09606 156 GGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPP------------QMGVPGMPGPADAGAQMGQQA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 236 HQQQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQLQvqaqgqpqvqgqggavqMPP 315
Cdd:pfam09606 224 QANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQP-----------------MGP 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 316 HSQQQQVLVPQMVQGQhsqmsalsqqQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQVQQV 395
Cdd:pfam09606 287 PGQQPGAMPNVMSIGD----------QNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGN 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 396 QQASQLTAVPGQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQP--------NSVSSGPTPSPGgFQPSPSPQPSQ 467
Cdd:pfam09606 357 FGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPqgpgsqppQSHPGGMIPSPA-LIPSPSPQMSQ 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 468 SPASSRTPQSYplqvpSPG-PLNTPGNpSSVMSPAGASqsEDQLYMDKLRQLSKYIEPLRRMINKIDKNEDRKKDLSKMK 546
Cdd:pfam09606 436 QPAQQRTIGQD-----SPGgSLNTPGQ-SAVNSPLNPQ--EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMK 507

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 547 SLLNILTDPNTRCPLKTLQKCEIALEklkNDMAVPtpppppvpctKKQYLCQPILDAVLANIRSPVFNHSLYRTFAPAMT 626
Cdd:pfam09606 508 RLLEILSNPSSRIPLETLQKCEAALE---NQMGTP----------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLE 574

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 627 AIHGPQITGPSIPSRKRKLEDDE---RQTIPNILQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLS 703
Cdd:pfam09606 575 ALFGPDIKGLPIPAKQPRLELDDttgRQEIPHILQGEIARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVS 654

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 704 IPADYPDQSPHWEDDGQQYEANPFLQTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQAC 763
Cdd:pfam09606 655 IPEDYPDQSPSCSLDEQEYNATPFLITVQKSLHARISKLPGLFSLSHLLDTWEMSVRQAC 714
 
Name Accession Description Interval E-value
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 17-763 2.42e-138

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 425.58  E-value: 2.42e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831  17 QKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKAQ-------------------GGP 77
Cdd:pfam09606   1 QSVVNKIEEALQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAqqqqpqggqgnggmgggqqGMP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831  78 DPINALQNLPGGvpgviGPRPPGAQMGGMGQMSMGPHAM--QGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQSIQFQT 155
Cdd:pfam09606  81 DPINALQNLAGQ-----GTRPQMMGPMGPGPGGPMGQQMggPGTASNLLASLGRPQMPMGGAGFPSQMSRVGRMQPGGQA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 156 FQPQQQQQATMQSQQPSAMFQQIRLQQLQQHHQNQQMQHQNQQQQQAqnqqqqnqlhqtRMQQQLQLQQLQQQQQQQQQL 235
Cdd:pfam09606 156 GGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPP------------QMGVPGMPGPADAGAQMGQQA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 236 HQQQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQLQvqaqgqpqvqgqggavqMPP 315
Cdd:pfam09606 224 QANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQP-----------------MGP 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 316 HSQQQQVLVPQMVQGQhsqmsalsqqQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQVQQV 395
Cdd:pfam09606 287 PGQQPGAMPNVMSIGD----------QNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGN 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 396 QQASQLTAVPGQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQP--------NSVSSGPTPSPGgFQPSPSPQPSQ 467
Cdd:pfam09606 357 FGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPqgpgsqppQSHPGGMIPSPA-LIPSPSPQMSQ 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 468 SPASSRTPQSYplqvpSPG-PLNTPGNpSSVMSPAGASqsEDQLYMDKLRQLSKYIEPLRRMINKIDKNEDRKKDLSKMK 546
Cdd:pfam09606 436 QPAQQRTIGQD-----SPGgSLNTPGQ-SAVNSPLNPQ--EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMK 507

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 547 SLLNILTDPNTRCPLKTLQKCEIALEklkNDMAVPtpppppvpctKKQYLCQPILDAVLANIRSPVFNHSLYRTFAPAMT 626
Cdd:pfam09606 508 RLLEILSNPSSRIPLETLQKCEAALE---NQMGTP----------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLE 574

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 627 AIHGPQITGPSIPSRKRKLEDDE---RQTIPNILQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLS 703
Cdd:pfam09606 575 ALFGPDIKGLPIPAKQPRLELDDttgRQEIPHILQGEIARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVS 654

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 704 IPADYPDQSPHWEDDGQQYEANPFLQTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQAC 763
Cdd:pfam09606 655 IPEDYPDQSPSCSLDEQEYNATPFLITVQKSLHARISKLPGLFSLSHLLDTWEMSVRQAC 714
 
Name Accession Description Interval E-value
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 17-763 2.42e-138

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 425.58  E-value: 2.42e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831  17 QKVVAQIEEAMRKAGTGHTKSSTEMESHVFTKAKTREEYLSMVARLIIHFRDIHKKAQ-------------------GGP 77
Cdd:pfam09606   1 QSVVNKIEEALQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAqqqqpqggqgnggmgggqqGMP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831  78 DPINALQNLPGGvpgviGPRPPGAQMGGMGQMSMGPHAM--QGVAGGQQGAGAAGPMQQMIQQQQQQQQQQQQQSIQFQT 155
Cdd:pfam09606  81 DPINALQNLAGQ-----GTRPQMMGPMGPGPGGPMGQQMggPGTASNLLASLGRPQMPMGGAGFPSQMSRVGRMQPGGQA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 156 FQPQQQQQATMQSQQPSAMFQQIRLQQLQQHHQNQQMQHQNQQQQQAqnqqqqnqlhqtRMQQQLQLQQLQQQQQQQQQL 235
Cdd:pfam09606 156 GGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPP------------QMGVPGMPGPADAGAQMGQQA 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 236 HQQQVHAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQSIQQMQQQQQLQvqaqgqpqvqgqggavqMPP 315
Cdd:pfam09606 224 QANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQP-----------------MGP 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 316 HSQQQQVLVPQMVQGQhsqmsalsqqQQLKLQQAMQARMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQVQQV 395
Cdd:pfam09606 287 PGQQPGAMPNVMSIGD----------QNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGN 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 396 QQASQLTAVPGQAQQMMSSPSPVQVQTPQSMPPPPQPQPSPQPPSSQP--------NSVSSGPTPSPGgFQPSPSPQPSQ 467
Cdd:pfam09606 357 FGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPqgpgsqppQSHPGGMIPSPA-LIPSPSPQMSQ 435

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 468 SPASSRTPQSYplqvpSPG-PLNTPGNpSSVMSPAGASqsEDQLYMDKLRQLSKYIEPLRRMINKIDKNEDRKKDLSKMK 546
Cdd:pfam09606 436 QPAQQRTIGQD-----SPGgSLNTPGQ-SAVNSPLNPQ--EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMK 507

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 547 SLLNILTDPNTRCPLKTLQKCEIALEklkNDMAVPtpppppvpctKKQYLCQPILDAVLANIRSPVFNHSLYRTFAPAMT 626
Cdd:pfam09606 508 RLLEILSNPSSRIPLETLQKCEAALE---NQMGTP----------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLE 574

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 627 AIHGPQITGPSIPSRKRKLEDDE---RQTIPNILQGEVARLNSKFLVNLDPSFCSNNGMVHLICKLDDKNLPSVPPLQLS 703
Cdd:pfam09606 575 ALFGPDIKGLPIPAKQPRLELDDttgRQEIPHILQGEIARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVS 654

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207158831 704 IPADYPDQSPHWEDDGQQYEANPFLQTVHKNMTSKLLQLPDKHSVTALLNTWAQSVRQAC 763
Cdd:pfam09606 655 IPEDYPDQSPSCSLDEQEYNATPFLITVQKSLHARISKLPGLFSLSHLLDTWEMSVRQAC 714
KIX_2 pfam16987
KIX domain; This KIX domain is an activator-binding domain.
 8-56 1.95e-03

KIX domain; This KIX domain is an activator-binding domain.


Pssm-ID: 465331  Cd Length: 83  Bit Score: 37.65  E-value: 1.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207158831   8 SDWR---SPAFRQKVVAQIEEAMRKA--GTGHTKSSTEM-------ESHVFTKAKTREEYL 56
Cdd:pfam16987   2 GDWRaqlPPEERQKVVNKIMETLKKIhlPNSGPEGLNELkkiavrfEEKIFTKASSKDDYL 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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