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    Set1 SET domain containing 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354971, updated on 17-Dec-2024

    Summary

    Official Symbol
    Set1provided by FlyBase
    Official Full Name
    SET domain containing 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040022
    Locus tag
    Dmel_CG40351
    See related
    AllianceGenome:FB:FBgn0040022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aaf45425 Dm; CG17395; CG17396; CG40351; Dmel\CG40351; dSet-1; dset1; dSet1; dSET1; l(3)h5; l5; set1; SET1; SetD1; SETD1
    Summary
    Enables histone H3K4 trimethyltransferase activity. Located in euchromatin and polytene chromosome. Part of Set1C/COMPASS complex. Is expressed in spermatozoon. Used to study neurodevelopmental disorder with speech impairment and dysmorphic facies. Human ortholog(s) of this gene implicated in early-onset epilepsy 2 and neurodevelopmental disorder with speech impairment and dysmorphic facies. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase) and SETD1B (SET domain containing 1B, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Set1 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (25107594..25115180)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3LHet NW_001848857.1 (593050..600636)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46483 Neighboring gene NADH dehydrogenase (ubiquinone) AGGG subunit Neighboring gene Ubiquinol-cytochrome c reductase 11 kDa subunit Neighboring gene Mediator complex subunit 21 Neighboring gene pseudo

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables histone H3K4 methyltransferase activity  
    enables histone H3K4 methyltransferase activity  
    enables histone H3K4 methyltransferase activity PubMed 
    enables histone H3K4 trimethyltransferase activity PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex  
    part_of Set1C/COMPASS complex PubMed 
    part_of Set1C/COMPASS complex  
    located_in euchromatin PubMed 
    located_in polytene chromosome PubMed 

    General protein information

    Preferred Names
    SET domain containing 1
    Names
    CG40351-PA
    CG40351-PB
    CG40351-PC
    CG40351-PD
    CG40351-PE
    CG40351-PF
    CG40351-PG
    CG40351-PH
    CG40351-PI
    SET domain-containing 1
    Set1-PA
    Set1-PB
    Set1-PC
    Set1-PD
    Set1-PE
    Set1-PF
    Set1-PG
    Set1-PH
    Set1-PI
    lethal 5
    lethal5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      25107594..25115180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170377.1 → NP_001163848.1  SET domain containing 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163848.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    2. NM_001110936.3 → NP_001104406.1  SET domain containing 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    3. NM_001015222.3 → NP_001015222.1  SET domain containing 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    4. NM_001170375.2 → NP_001163846.1  SET domain containing 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163846.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    5. NM_001170376.2 → NP_001163847.1  SET domain containing 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    6. NM_001170380.2 → NP_001163851.1  SET domain containing 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    7. NM_001015221.3 → NP_001015221.1  SET domain containing 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015221.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    8. NM_001170378.1 → NP_001163849.1  SET domain containing 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    9. NM_001170379.1 → NP_001163850.1  SET domain containing 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9WDY6, Q4V706, Q5LJZ2, Q8SXR9
      Conserved Domains (6) summary
      smart00317
      Location:1504 → 1625
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:1463 → 1641
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd12304
      Location:99 → 191
      RRM_Set1; RNA recognition motif in the Set1-like family of histone-lysine N-methyltransferases
      pfam08648
      Location:255 → 380
      DUF1777; Protein of unknown function (DUF1777)
      pfam11764
      Location:1341 → 1492
      N-SET; COMPASS (Complex proteins associated with Set1p) component N
      pfam12871
      Location:318 → 388
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
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